{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:46:12Z","timestamp":1774525572704,"version":"3.50.1"},"reference-count":10,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Pheochromocytoma is a rare adrenal tumor characterized by the secretion of catecholamines and vasoactive peptides. It can cause a catecholaminergic storm and lead to acute coronary syndromes. We present the case of a 53-year-old man, without any medical history, who arrived to the hospital following a spinal trauma due a fall. He presents back and retrosternal pain, with a clinical status of acute pulmonary edema, sinus tachycardia with left bundle branch block, left ventricular apical ballooning with depressed systolic function. Blood tests show a very important increase of Troponin and transaminases. A contrast chest-abdomen CT highlighted a right adrenal solid mass, with a diameter of 78mm, partial capsular laceration, compression of the inferior vena cava and the hepatic parenchyma. The clinical condition of the patient rapidly worsens from a respiratory and hemodynamic point of view, with cardiogenic shock, anuria and sepsis, refractory to all the medical treatments, until the patient died. The autopsy confirmed that the abdominal mass was a pheochromocytoma, broken after the trauma suffered. The resulting catecholaminergic storm caused a myocardial ischemia with Takotsubo syndrome, with cardiogenic shock. This unfortunate case confirms the pheochromocytoma as important risk factor for the onset of Takotsubo syndrome, and the how dramatic and severe a catecholaminergic storm can be.<\/jats:p>","DOI":"10.4081\/monaldi.2021.1711","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T09:29:22Z","timestamp":1615454962000},"source":"Crossref","is-referenced-by-count":3,"title":["Takotsubo syndrome and pheochromocytoma: an insidious combination"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-5570","authenticated-orcid":false,"given":"Stefano","family":"Maff\u00e8","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierfranco","family":"Dellavesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Paffoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bergamasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisa","family":"Arrondini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Facchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Prenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Baduena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Careri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Franchetti Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Parravicini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"1665","doi-asserted-by":"crossref","unstructured":"Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 2008;155:408-17.","DOI":"10.1016\/j.ahj.2007.11.008"},{"key":"1666","unstructured":"Yuan S, He T, Yang L, Chu Q, Huang W, Dai H. Basal Takotsubo syndrome induced by pheochromocytoma rupture. Cardiovasc J Afr 2020; 1:1-4."},{"key":"1667","doi-asserted-by":"crossref","unstructured":"Hassan S. Clinical features and outcome of Pheochromocytoma-inducedTakotsubo syndrome: analysis of 80 published cases. Am J Cardiol 2016;117:1836\u00e2\u20ac\u201c44.","DOI":"10.1016\/j.amjcard.2016.03.019"},{"key":"1668","doi-asserted-by":"crossref","unstructured":"Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ et al. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. Eur Heart J 2018;39:2032-46.","DOI":"10.1093\/eurheartj\/ehy076"},{"key":"1669","doi-asserted-by":"crossref","unstructured":"Hassan S, Falhammar H. Pheochromocytoma- and paraganglioma-triggered Takotsubo syndrome. Endocrine 2019;65:483\u00e2\u20ac\u201c93.","DOI":"10.1007\/s12020-019-02035-3"},{"key":"1670","doi-asserted-by":"crossref","unstructured":"Wittstein IS, Thiemann DR, Lima JA, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 2005;352:539-48.","DOI":"10.1056\/NEJMoa043046"},{"key":"1671","doi-asserted-by":"crossref","unstructured":"Park JH, Kang SJ, Song JK, et al. Left ventricular apical ballooning due to severe physical stress in patients admitted to the medical ICU. Chest 2005;128:296-302.","DOI":"10.1378\/chest.128.1.296"},{"key":"1672","doi-asserted-by":"crossref","unstructured":"Lenders JWM, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet 2005;366:665\u00e2\u20ac\u201c75.","DOI":"10.1016\/S0140-6736(05)67139-5"},{"key":"1673","doi-asserted-by":"crossref","unstructured":"Garwal V, Kant G, Hans N, Messerli FH. Takotsubo-like cardiomyopathy in pheochromocytoma. Int J Cardiol 2011;153:241\u00e2\u20ac\u201c8.","DOI":"10.1016\/j.ijcard.2011.03.027"},{"key":"1674","doi-asserted-by":"crossref","unstructured":"Arcovitz PA, Czako P, Rosenblatt S, Billecke SS. Pheochromocytoma presenting with Takotsubo syndrome. J Interv Cardiol 2010;23:437\u00e2\u20ac\u201c42.","DOI":"10.1111\/j.1540-8183.2010.00551.x"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/download\/1711\/1201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/download\/1711\/1201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T12:29:34Z","timestamp":1616675374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/view\/1711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,9]]},"references-count":10,"URL":"https:\/\/doi.org\/10.4081\/monaldi.2021.1711","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,9]]}}}