{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:53:53Z","timestamp":1787500433158,"version":"build-2736575974"},"reference-count":17,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Differentiation between exudative and transudative pleural effusion is sometime problematic. This study aimed to evaluate the diagnostic value of C-reactive protein (CRP) in differentiation of exudative and transudative pleural effusion. This is an analytical epidemiologic cross-sectional study that evaluates the role of CRP in differentiating transudative and exudative pleural effusion. Patients were divided into two groups of exudates and transudates, based on Light\u2019s criteria. The pleural effusion CRP levels were compared between the two groups. SPSS software version 16 was used for statistical analysis. The significance level was considered p&lt;0.05. A total of 169 patients with pleural effusion enrolled in the study. Based on Light's criteria, 108 patients (63.9%) had exudative pleural effusion and 61 (36.1%) had transudative pleural effusion. The level of CRP in the pleural fluid of patients in the exudative and transudative groups was 13.3\u00b137.1 and 3.5\u00b14.3mg\/dl, respectively (p=0.008). The 3.31 mg\/dl cut-off point of CRP level of pleural effusion had the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96.3%, 72.1%, 86% and 91.7% respectively. \u00a0The results obtained in our study shows that the level of CRP in the effusion fluid can be helpful in differentiating exudative from transudative pleural effusions.<\/jats:p>","DOI":"10.4081\/monaldi.2022.2059","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T04:58:49Z","timestamp":1647320329000},"source":"Crossref","is-referenced-by-count":3,"title":["Role of CRP as a marker for discrimination of exudative and transudative pleural effusion"],"prefix":"10.4081","author":[{"given":"Omid","family":"Rismantab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Aili Javad","family":"Moosavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Farahnak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Dastoorpoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Raji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"15211","doi-asserted-by":"crossref","unstructured":"Porcel JM, Light RW. 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Eur J Med 1992;1:201-7."},{"key":"15216","doi-asserted-by":"crossref","unstructured":"Garcia-Pachon E, Llorca I. Diagnostic value of C-reactive protein in exudative pleural effusions. Eur J Intern Med 2002;13:246-9.","DOI":"10.1016\/S0953-6205(02)00036-5"},{"key":"15217","doi-asserted-by":"crossref","unstructured":"Aleman C, Alegre J, Monasterio J, et al. Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions. Clin Sci 2003;105:601-7.","DOI":"10.1042\/CS20030115"},{"key":"15218","doi-asserted-by":"crossref","unstructured":"Marel M, \u0160tastny B, Melinov\u00e1 L, et al. Diagnosis of pleural effusions: experience with clinical studies, 1986 to 1990. Chest 1995;107:1598-603.","DOI":"10.1378\/chest.107.6.1598"},{"key":"15219","doi-asserted-by":"crossref","unstructured":"Gewurz H, Mold C, Siegel J, Fiedel B. C-reactive protein and the acute phase response. 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Pleural fluid C-reactive protein contributes to the diagnosis and assessment of severity of parapneumonic effusions. Eur J Intern Med 2012;23:447-50.","DOI":"10.1016\/j.ejim.2012.03.002"},{"key":"15224","doi-asserted-by":"crossref","unstructured":"Daniil ZD, Zintzaras E, Kiropoulos T, et al. Discrimination of exudative pleural effusions based on multiple biological parameters. Eur Respir J 2007;30:957-64.","DOI":"10.1183\/09031936.00126306"},{"key":"15225","doi-asserted-by":"crossref","unstructured":"Kapisyzi P, Argjiri D, Byrazeri G, et al. Use of pleural fluid c-reactive protein level as a diagnostic marker for pleural effusions. Chest 2009;136:30S.","DOI":"10.1378\/chest.136.4_MeetingAbstracts.30S-f"},{"key":"15226","unstructured":"Gabhale D, Taparia P, Yadav D, Agnihotri S. Usefulness of pleural fluid CRP level in differential diagnosis of exudative pleural effusion - a pilot study. Int J Clin Biochem Res 2015;2:97-109."},{"key":"15227","doi-asserted-by":"crossref","unstructured":"Skouras V, Boultadakis E, Nikoulis D, et al. Prognostic value of C\u2010reactive protein in parapneumonic effusions. 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