{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:16:07Z","timestamp":1760426167944,"version":"3.40.5"},"reference-count":13,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>The systemic immune-inflammation index (SII) is a novel inflammatory biomarker. Simple and complicated para-pneumonic effusion (PPE) are two significant complications of pneumonia. We evaluated the efficacy of the systemic immune inflammation index (SII) to differentiate between the two. Records of all children up to 18 years of age admitted between April 2019 and September 2022 and diagnosed with Simple or complicated PPE were retrospectively evaluated. SII and other biomarkers were compared between both groups. ROC with the Youden index was used to estimate the discriminative value of SII. Fifty children were enrolled with a median (IQR) age of 81.5 (36.7, 133.5) months; 31 (62%) were male. Thirty-one (62%) had complicated PPE, and 19 (38%) had simple PPE. SII was significantly higher in complicated PPE (p=0.007). Good areas under the curve (AUCs) were found for CRP (0.771) and SII (0.736) to differentiate complicated from simple PPE. The best cut-off value for SII to differentiate complicated PPE from simple PPE was 1557\u00d7103\u00b5L, with a sensitivity of 82.4% and specificity of 57.6%. SII can be used as a screening tool to differentiate between complicated and simple PPE at the time of presentation.<\/jats:p>","DOI":"10.4081\/monaldi.2023.2652","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:25:51Z","timestamp":1694078751000},"source":"Crossref","is-referenced-by-count":1,"title":["Utility of systemic immune-inflammation Index as a serum biomarker to differentiate between complicated and simple para-pneumonic effusion"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-8815","authenticated-orcid":false,"given":"Nikhil","family":"Rajvanshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-8097","authenticated-orcid":false,"given":"Prawin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7198-6909","authenticated-orcid":false,"given":"Jagdish Prasad","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"30703","unstructured":"Wolrd Health Organization. Pneumonia in children. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/pneumonia"},{"key":"30704","doi-asserted-by":"crossref","unstructured":"Sahn SA. Diagnosis and management of parapneumonic effusions and empyema. Clin Infect Dis 2007;45:1480-6.","DOI":"10.1086\/522996"},{"key":"30705","doi-asserted-by":"crossref","unstructured":"Light RW. Parapneumonic effusions and empyema. Proc Am Thorac Soc 2006;3:75-80.","DOI":"10.1513\/pats.200510-113JH"},{"key":"30706","doi-asserted-by":"crossref","unstructured":"G\u00fcneylio\u011flu MM, G\u00fcng\u00f6r A, G\u00f6ktu\u011f A, et al. Evaluation of the efficiency of the systemic immune-inflammation index in differentiating parapneumonic effusion from empyema. Pediatr Pulmonol 2022;57:1625-30.","DOI":"10.1002\/ppul.25926"},{"key":"30707","doi-asserted-by":"crossref","unstructured":"Bradley JS, Byington CL, Shah SS, et al. The Management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis 2011;53:e25-76.","DOI":"10.1093\/cid\/cir531"},{"key":"30708","doi-asserted-by":"crossref","unstructured":"Florin TA, Ambroggio L, Brokamp C, et al. Biomarkers and disease severity in children with community-acquired pneumonia. Pediatrics 2020;145:e20193728.","DOI":"10.1542\/peds.2019-3728"},{"key":"30709","doi-asserted-by":"crossref","unstructured":"Lahti E, Peltola V, Virkki R, et al. Development of parapneumonic empyema in children. Acta Paediatr 2007;96:1686-92.","DOI":"10.1111\/j.1651-2227.2007.00511.x"},{"key":"30710","doi-asserted-by":"crossref","unstructured":"Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 2014;20:6212-22.","DOI":"10.1158\/1078-0432.CCR-14-0442"},{"key":"30711","unstructured":"Calkins CM, St Peter SD, Holcomb GW, III. Empyema. In: L. Spitz and A.G. Coran, editors. Operative Pedratic Surgery. Boca Raton: CRC Press; 2022. p. 217-24."},{"key":"30712","doi-asserted-by":"crossref","unstructured":"Sevinc C, Demirci R, Timur O. Predicting hospital mortality in COVID-19 hemodialysis patients with developed scores. Semin Dial 2021;34347-59.","DOI":"10.1111\/sdi.13004"},{"key":"30713","doi-asserted-by":"crossref","unstructured":"Patel KM, Ullah K, Patail H, Ahmad S. Ultrasound for pleural disease: Beyond a pocket of pleural fluid. Ann Am Thorac Soc 2021;18:749-56.","DOI":"10.1513\/AnnalsATS.202008-948CME"},{"key":"30714","doi-asserted-by":"crossref","unstructured":"Saricam M. Efficiency of lymphocyte-to-monocyte ratio in differential diagnosis of parapneumonic effusion and thoracic empyema. Surg Infect (Larchmt) 2020;21:891-4.","DOI":"10.1089\/sur.2019.346"},{"key":"30715","doi-asserted-by":"crossref","unstructured":"Li D, Shen Y, Qin J, et al. Diagnostic performance of C-reactive protein for parapneumonic pleural effusion: a meta-analysis. Ann Transl Med 2019;7:1.","DOI":"10.21037\/atm.2018.11.44"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/download\/2652\/1741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/download\/2652\/1741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:25:58Z","timestamp":1694078758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/view\/2652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":13,"URL":"https:\/\/doi.org\/10.4081\/monaldi.2023.2652","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"type":"electronic","value":"2532-5264"},{"type":"print","value":"1122-0643"}],"subject":[],"published":{"date-parts":[[2023,9,7]]}}}