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Typically, identifying the virus in the patient\u2019s respiratory secretions is important for laboratory validation of a clinically suspected RSV infection. Unfortunately, the only available preventive measure to lower the incidence for infants who are at high risk of RSV-induced hospitalization is palivizumab prophylaxis. Treatment strategies to manage RSV involve using an antiviral drug, ribavirin, along with bronchodilators, nebulized adrenaline (epinephrine), and nebulized hypertonic saline. Providing patients with alternative treatment options like vitamin D-cathelicidin as well as probiotics and prebiotics can help reduce the intensity of the infection. This review article focuses on the epidemiology, clinical manifestation, prophylaxis, and available treatment options for RSV infections in infants, children, and young adults.<\/jats:p>","DOI":"10.4081\/monaldi.2024.2888","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T07:17:04Z","timestamp":1728026224000},"source":"Crossref","is-referenced-by-count":1,"title":["Respiratory syncytial virus: an overview of clinical manifestations and management in the Indian pediatric population"],"prefix":"10.4081","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8821-8877","authenticated-orcid":false,"given":"Abhishek","family":"B J","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agadi Hiremath Viswanatha","family":"Swamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanatkumar Bharamu","family":"Nyamagoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namratha","family":"D","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"45201","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10052"},{"key":"45202","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8368-9"},{"key":"45203","doi-asserted-by":"publisher","DOI":"10.1542\/pir.35.12.519"},{"key":"45204","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3289-4"},{"key":"45205","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2106062"},{"key":"45206","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01783-8"},{"key":"45207","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.10.041"},{"key":"45208","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-016-0252-9"},{"key":"45209","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801105010128"},{"key":"45210","unstructured":"Piedimonte G, Perez MK. Respiratory syncytial virus infection and bronchiolitis practice gaps."},{"key":"45211","doi-asserted-by":"publisher","DOI":"10.4103\/ijmm.IJMM_19_5"},{"key":"45212","unstructured":"Petrocelli PA, Cunsolo V, Melito M, et al. Diagnosis of respiratory syncytial virus (RSV) infection in children by respiratory panel utilized during the COVID-19 pandemic. Annali Istituto Superiore Sanit\u00e0 2023;59:31-6."},{"key":"45213","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir047"},{"key":"45214","doi-asserted-by":"publisher","DOI":"10.1177\/2049936119865798"},{"key":"45215","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00511-0"},{"key":"45216","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80008-8"},{"key":"45217","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198208123070702"},{"key":"45218","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25265-4"},{"key":"45219","unstructured":"Brady MT, Byington CL, Davies HD, et al. Updated guidance for palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection. Pediatrics 2014;134:e620-38."},{"key":"45220","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2022.128"},{"key":"45221","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30938-8"},{"key":"45222","doi-asserted-by":"publisher","DOI":"10.1086\/313960"},{"key":"45223","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913556"},{"key":"45224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1601366"},{"key":"45225","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10030256"},{"key":"45226","unstructured":"McNally JD, McEvoy CT. Immunomodulatory therapy for the prevention and treatment of respiratory syncytial virus infection. Pediatr Allergy Immunol Pulmonol 2019;32:99-106."},{"key":"45227","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"45228","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1617-7"},{"key":"45229","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2018-0260"},{"key":"45230","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1914"},{"key":"45231","unstructured":"McDade P. Assessing Clinical Outcomes of the 2014 American Academy of Pediatrics Bronchiolitis Guideline. 2018. 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