{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:09:16Z","timestamp":1784282956147,"version":"3.55.0"},"reference-count":12,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Living donor liver transplantation (LDLT) is a lifesaving procedure that is often curative for several liver diseases. Familial hypercholesterolemia (FH) is a metabolic disease that results from an autosomal dominant mutation in the low-density lipoprotein receptor; yet, young patients with FH can live years without detection. Herein, we report a case of a patient who developed early myocardial infarction (MI) after having a transplant from a donor with undetected heterozygous FH. The patient was a 67-year-old female with non-alcoholic steatohepatitis-related liver cirrhosis, free from coronary artery disease, who underwent LDLT from her daughter, a 45-year-old female with no past medical history. One year post-transplantation, she presented with an acute MI with a large atherosclerotic burden. Genetic analysis confirmed heterozygous FH in the donor but not in the recipient. This case emphasizes the importance of incorporating a thorough clinical history and lipid profile into pre-transplant testing for both the recipient and donor, as well as aggressive lipid-lowering therapy post-transplantation to avoid cardiovascular complications.<\/jats:p>","DOI":"10.4081\/monaldi.2024.2907","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:07:24Z","timestamp":1705378044000},"source":"Crossref","is-referenced-by-count":1,"title":["Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link"],"prefix":"10.4081","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6914-0730","authenticated-orcid":false,"given":"Naji","family":"Kholaif","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3844-6070","authenticated-orcid":false,"given":"Lin","family":"Batha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-0737","authenticated-orcid":false,"given":"Isra","family":"Elmahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulaiman","family":"Alnasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1234-3607","authenticated-orcid":false,"given":"Sultan","family":"Alzaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah","family":"Almallohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosaad","family":"Alhussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1492-3795","authenticated-orcid":false,"given":"Dana","family":"Alhalees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alshehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"55262","doi-asserted-by":"crossref","unstructured":"Goldaracena N, Barbas AS. Living donor liver transplantation. Curr Opin Organ Transplant 2019;24:131-7.","DOI":"10.1097\/MOT.0000000000000610"},{"key":"55263","doi-asserted-by":"crossref","unstructured":"Trotter JF. Selection of donors for living donor liver transplantation. Liver Transpl 2003;9:S2-7.","DOI":"10.1053\/jlts.2003.50221"},{"key":"55264","doi-asserted-by":"crossref","unstructured":"Neuberger J. An update on liver transplantation: a critical review. J Autoimmun 2016;66:51-9.","DOI":"10.1016\/j.jaut.2015.08.021"},{"key":"55265","doi-asserted-by":"crossref","unstructured":"Nikkil\u00e4 K, \u00c5berg F, Isoniemi H. Transmission of LDLR mutation from donor through liver transplantation resulting in hypercholesterolemia in the recipient. Am J Transplant 2014;14:2898-902.","DOI":"10.1111\/ajt.12961"},{"key":"55266","doi-asserted-by":"crossref","unstructured":"Kholaif N, Mohamed TI, Alharbi IS, et al. Management and clinical outcomes of patients with homozygous familial hypercholesteremia in Saudi Arabia. Monaldi Arch Chest Dis 2023;93. doi:10.4081\/monaldi.2023.2503","DOI":"10.4081\/monaldi.2023.2503"},{"key":"55267","doi-asserted-by":"crossref","unstructured":"Al-Rasadi K, Al-Waili K, Al-Sabti HA, et al. Criteria for diagnosis of familial hypercholesterolemia: a comprehensive analysis of the different guidelines, appraising their suitability in the Omani Arab population. Oman Med J 2014;29:85-91.","DOI":"10.5001\/omj.2014.22"},{"key":"55268","doi-asserted-by":"crossref","unstructured":"Setia N, Saxena R, Arora A, Verma IC. Spectrum of mutations in homozygous familial hypercholesterolemia in India, with four novel mutations. Atherosclerosis 2016;255:31-6.","DOI":"10.1016\/j.atherosclerosis.2016.10.028"},{"key":"55269","doi-asserted-by":"crossref","unstructured":"Gilroy R, Heronemus M, Schmitt T, Moriarty P. Donors with familial hypercholesterolemia and clinical outcome in liver transplant recipients. Transplantation 2014;98:796.","DOI":"10.1097\/00007890-201407151-02729"},{"key":"55270","doi-asserted-by":"crossref","unstructured":"Popescu I, Habib N, Dima S, et al. Domino liver transplantation using a graft from a donor with familial hypercholesterolemia: seven-yr follow-up. Clin Transplant 2009;23:565-70.","DOI":"10.1111\/j.1399-0012.2008.00935.x"},{"key":"55271","doi-asserted-by":"crossref","unstructured":"Liu C, Niu DM, Loong CC, et al. Domino liver graft from a patient with homozygous familial hypercholesterolemia. Pediatr Transplant 2010;14:E30-3.","DOI":"10.1111\/j.1399-3046.2009.01133.x"},{"key":"55272","doi-asserted-by":"crossref","unstructured":"Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008;359:2195-207.","DOI":"10.1056\/NEJMoa0807646"},{"key":"55273","unstructured":"He K, Wang J, Shi H, et al. An interspecies study of lipid profiles and atherosclerosis in familial hypercholesterolemia animal models with low-density lipoprotein receptor deficiency. Am J Transl Res 2019;11:3116-27."}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/2907\/1847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/2907\/1847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T09:53:44Z","timestamp":1784282024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/2907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,31]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2024.2907","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}