{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T22:49:46Z","timestamp":1770245386588,"version":"3.49.0"},"reference-count":17,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>The management of persistent malignant pleural effusion (MPE) or uremic pleural effusions requires the removal of pleural fluid and the prevention of recurrence through pleurodesis. Pleurodesis involves injecting a sclerosing agent into the pleura to encourage adhesion between the two layers, ultimately obliterating the pleural space. Povidone-iodine is a potential pleurodesing agent. This quasi-experimental study was conducted at the Department of Pulmonology, Shaikh Zayed Hospital, Federal Postgraduate Medical Institute, Lahore, Pakistan, over 1 year (March 2021 - March 2022). A total of 70 patients with MPE, uremic pleural effusions, and secondary spontaneous pneumothorax (SSP) were enrolled after meeting the inclusion criteria. The pleurodesis procedure involved administering a mixture of 20 mL of 10% povidone-iodine solution and 30 mL of normal saline through a chest tube, followed by clamping for 3 hours. Patients were scheduled for follow-up visits at 2, 4, 8, and 12 weeks. Data was analyzed using SPSS version 20.0. The average age of participants was 53.26 years (+13.71). Of the 70 patients, 39 (55.7%) were male and 31 (44.3%) were female. 62 patients (88.57%) had pleural effusion, and 8 patients (11.42%) had pneumothorax. The procedure was successful in 84.3% of patients, with varying success rates by diagnosis: MPE (81%), uremic pleural effusion (92%), and SSP (75%). Statistical analysis revealed significant positive effects of povidone-iodine on procedure outcomes (p=0.048) and effectiveness in preventing pleural effusion recurrence (p=0.028). This study indicates that 10% povidone-iodine can serve as a viable alternative to other pleurodesis agents, yielding standard-quality pleurodesis in 84.3% of patients. It is readily available, cost-effective, and has minimal adverse effects.<\/jats:p>","DOI":"10.4081\/monaldi.2024.3197","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:12:19Z","timestamp":1734513139000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of povidone-iodine as an effective pleurodesing agent: an experience from a teaching hospital"],"prefix":"10.4081","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3122-1383","authenticated-orcid":false,"given":"Hasnain","family":"Mahboob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4585-0765","authenticated-orcid":false,"given":"Talha","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"48350","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp010731"},{"key":"48351","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.16341"},{"key":"48352","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.1.184"},{"key":"48353","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2012.00722.x"},{"key":"48354","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136986"},{"key":"48355","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-015-0412-7"},{"key":"48356","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-015-0270-5"},{"key":"48357","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2022-219784"},{"key":"48358","unstructured":"Light RW. Pleural effusion due to miscellaneous diseases. In: Pleural diseases. 6th ed. 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