{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:39:12Z","timestamp":1775554752821,"version":"3.50.1"},"reference-count":18,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>This cross-sectional study aimed to investigate the role of peak inspiratory flow rate (PIFR) in the management of inhalation therapy for patients with chronic obstructive pulmonary disease (COPD). Conducted in the Department of Pulmonary Medicine at a tertiary care institute from July 2021 to January 2022, this study included a total of 351 patients who were clinically diagnosed with stable COPD and currently receiving inhaler therapy. Participants underwent comprehensive assessments that included demographic data collection, the use of the ABCD assessment tool to evaluate disease severity, the COPD Assessment Test (CAT) for quality of life measurement, and assessments for adherence to inhaler therapy and inhaler technique proficiency. The primary focus was on determining the prevalence of suboptimal PIFR and identifying associated demographic and clinical factors. The results indicated that 45% of the patients exhibited suboptimal PIFR, which is critical for effective medication delivery in COPD management. Analysis revealed several significant predictors of suboptimal PIFR: female gender, lower CAT scores, the type of inhaler device used, and a Modified Medical Research Council grade of \u22652, which indicates increased levels of breathlessness. These findings underscore the importance of assessing PIFR in COPD patients to ensure effective drug delivery. The study suggests that personalized inhaler device prescriptions tailored to individual PIFR can enhance treatment efficacy and improve overall management outcomes for COPD patients. By addressing factors contributing to suboptimal PIFR, healthcare providers can optimize inhalation therapy and ultimately improve patient quality of life.<\/jats:p>","DOI":"10.4081\/monaldi.2024.3210","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:12:44Z","timestamp":1735017164000},"source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and predictors of suboptimal peak inspiratory flow rates in the management of chronic obstructive pulmonary disease"],"prefix":"10.4081","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-4284","authenticated-orcid":false,"given":"Madhusmita Mohanty","family":"Mohapatra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-3213","authenticated-orcid":false,"given":"Mahesh Babu","family":"Vemuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod Kumar","family":"Saka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratap","family":"Upadhya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnukanth","family":"Govindharaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"48646","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00511-7"},{"key":"48647","unstructured":"World Health Organization. Projections of mortality and causes of death, 2016 and 2060. Available from: https:\/\/colinmathers.com\/2022\/05\/10\/projections-of-global-deaths-from-2016-to-2060\/. Accessed: July 2023."},{"key":"48648","unstructured":"India State-Level Disease Burden Initiative CRD Collaborators. The burden of chronic respiratory diseases and their heterogeneity across the states of India: the Global Burden of Disease Study 1990-2016. Lancet Glob Health 2018;6:e1363-74."},{"key":"48649","unstructured":"Newman SP. Principles of metered-dose inhaler design. Respir Care 2005;50:1177-90."},{"key":"48650","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00024807"},{"key":"48651","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2013.1038"},{"key":"48652","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.4.3.2017.0183"},{"key":"48653","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105298"},{"key":"48654","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S195438"},{"key":"48655","unstructured":"Loh CH, Lovings TM, Ohar JA. Low inspiratory flow rates predict COPD and all-cause readmissions, in A23. Understanding and reducing copd rehospitalizations. Available from: https:\/\/www.atsjournals.org\/doi\/abs\/10.1164\/ajrccm-conference.2016.193.1_MeetingAbstracts.A1125."},{"key":"48656","unstructured":"Ghosh S, Pleasants RA, Donohue JF, et al. Device-specific suboptimal peak inspiratory flow rates are common in chronic obstructive pulmonary disease, in B33. COPD: maintenance therapy. 2018, Am J Respir Crit Care Med 2008;197:A3034."},{"key":"48657","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2012.0987"},{"key":"48658","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.4.3.2017.0155"},{"key":"48659","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201611-903OC"},{"key":"48660","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01674-5"},{"key":"48661","doi-asserted-by":"publisher","DOI":"10.4103\/ijrc.ijrc_2_18"},{"key":"48662","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227737"},{"key":"48663","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.6.3.2018.0163"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3210\/1992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3210\/1992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:33:52Z","timestamp":1768988032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/3210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,31]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2024.3210","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,24]]}}}