{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:41:55Z","timestamp":1776076915200,"version":"3.50.1"},"reference-count":38,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>High blood levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown in various malignancies. In lung cancer, the importance of NT-proBNP is not clear. In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage, tumor diameter, histopathology, and specific sites of mediastinal metastasis: lymphadenopathy; pericardial, cardiac, major vessel, other mediastinal organ or lymphatic involvement\/invasion. A total of 105 lung cancer and 120 control patients (chronic obstructive lung disease, interstitial lung disease, pulmonary thromboembolism, and pneumonia; 30\/subgroup) with measured NT-proBNP levels were included retrospectively. Demographics, comorbidities, and echocardiographic findings in all patients, as well as histologic subtype, diameter, stage, and radiologic and\/or pathologic mediastinal involvement\/invasion of the tumor to the mediastinum in patients with lung cancer, were studied with regard to blood NT-proBNP levels. When lung cancer and control groups were compared globally or as subgroups with comorbidities, NT-proBNP levels did not show meaningful differences. However, NT-proBNP levels were determined to be 249 pg\/mL and 88 pg\/mL in lung cancer (n=68) and control subgroups (n=58) without comorbidities, respectively (p=0.001). Among lung cancer patients without comorbidities and those with cardiac, pericardial, major vascular, or other mediastinal involvement\/invasion (lymphadenopathy, lymphatic, or other organ invasion) (n=27), the NT-proBNP level was 303 pg\/mL, whereas it was 166 pg\/mL in those without these mediastinal invasions (n=41) (p=0.031). There is a need for much larger, randomized studies to obtain evidence for the potential role of NT-proBNP as a helpful diagnostic biomarker for lung cancer. Clinical suspicion of malignancy may be raised if high NT-proBNP levels cannot be explained by all other risk factors and disorders or diseases. Furthermore, pericardial, cardiac, major vessel, or other mediastinal invasion\/involvement should be sought when high NT-proBNP levels are determined in lung cancer patients without any comorbidities or risk factors for high NT-proBNP levels.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3174","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T07:58:22Z","timestamp":1737964702000},"source":"Crossref","is-referenced-by-count":0,"title":["Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer"],"prefix":"10.4081","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-7488","authenticated-orcid":false,"given":"Sinem","family":"\u0130nan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9703-9598","authenticated-orcid":false,"given":"Semra","family":"Bila\u00e7ero\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6308","authenticated-orcid":false,"given":"Burcu","family":"Uluda\u011f Artun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"51156","unstructured":"Midthun DE, Lilenbaum RC, Schild SE, Vora SR. Overview of the initial treatment and prognosis of lung cancer. Available from: https:\/\/www.uptodate.com\/contents\/overview-of-the-initial-treatment-and-prognosis-of-lung-cancer."},{"key":"51157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.09.009"},{"key":"51158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.08.032"},{"key":"51159","unstructured":"Chen HH, Colucci WS. Natriuretic peptide measurement in non-heart failure settings. 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