{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:07:05Z","timestamp":1789776425960,"version":"4.0.1"},"reference-count":22,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>The management of malignant pleural effusion (MPE) is influenced by the lung\u2019s ability to re-expand following fluid drainage. Lung entrapment can complicate this process and may be predicted using pleural manometry. Recently, a novel lung ultrasound (LUS) marker\u2014the sinusoidal sign\u2014has emerged as a potential tool to differentiate between expandable and entrapped lung prior to thoracentesis. A prospective observational study was conducted to evaluate the role of pre-drainage LUS in identifying entrapped lung and compare its diagnostic accuracy with pleural manometry. A total of 30 patients with MPE were enrolled. Prior to thoracentesis, targeted ipsilateral LUS was performed at the level of the atelectatic lung. M-mode displacement &lt;1 mm was considered indicative of an absent sinusoidal sign. Simultaneously, pleural manometry was conducted during thoracentesis to measure pressure changes and calculate pleural elastance. Lung expandability was determined based on pleural elastance and post-thoracentesis imaging findings (computed tomography thorax). A pleural elastance &gt;13.6 cm H2O\/L was considered diagnostic of lung entrapment. A pleural elastance cut-off of 13.6 cm H2O\/L demonstrated 100% sensitivity, 93% specificity, a 100% positive predictive value, and 84.2% negative predictive value. The absence of the sinusoidal sign on LUS had a sensitivity of 78.6% and specificity of 100% in identifying entrapped lung. Both absent sinusoidal sign on pre-drainage LUS and elevated pleural elastance (&gt;13.6 cm H2O\/L) during thoracentesis are reliable indicators of lung entrapment in MPE. LUS may serve as a useful, non-invasive bedside tool for early identification of nonexpandable lung.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3263","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:44:20Z","timestamp":1750311860000},"source":"Crossref","is-referenced-by-count":1,"title":["Use of a novel ultrasound sign in the management of malignant pleural effusions: a prospective observational trial"],"prefix":"10.4081","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3982-8468","authenticated-orcid":true,"given":"Pradeep","family":"Bajad","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Amrita School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Dutt","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Caritas Hospital, Kottayam, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Caritas Hospital, Kottayam, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5857-2587","authenticated-orcid":true,"given":"Amartya","family":"Chakraborti","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Manipal Hospital, Kolkata, West Bengal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-374X","authenticated-orcid":true,"given":"Rishabh","family":"Kochar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Delhi Heart and Lung Institute, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-2786","authenticated-orcid":true,"given":"Saumya","family":"Shishir","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Yatharth Hospital, Noida, Uttar Pradesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"58197","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12496"},{"key":"58198","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31821981a3"},{"key":"58199","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<905::AID-CNCR2820560435>3.0.CO;2-U"},{"key":"58200","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.08.026"},{"key":"58201","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1415ST"},{"key":"58202","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.5.ats8-00"},{"key":"58203","unstructured":"Naito T, Satoh H, Ishikawa H, et al. 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