{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:59:35Z","timestamp":1790125175418,"version":"4.0.1"},"reference-count":12,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>To evaluate the relationship between fractional exhaled nitric oxide (FeNO), asthma control test (ACT), and spirometry measurements in individuals with asthma receiving treatment, a cross-sectional study was conducted involving 47 diagnosed asthmatic patients. FeNO levels were measured using Eversens Evernoa FeNO, ACT scores were recorded, and spirometry (pre- and post-bronchodilator) was conducted. Correlations between these parameters were analyzed using Pearson\u2019s correlation and t-tests. The study found no statistically significant correlation between FeNO and spirometry parameters [forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1\/FVC] or ACT scores. While FeNO was higher in individuals without a family history of asthma and nonsmokers, these differences were not statistically significant. Additionally, spirometry parameters showed significant improvement after bronchodilator use, but FeNO did not strongly predict lung function improvement. The findings suggest that while FeNO is useful as an indicator of airway inflammation, it may not consistently correlate with functional lung measurements or asthma control as assessed by spirometry and ACT. This highlights the need for a multidimensional approach to asthma management that combines these tools for more comprehensive disease assessment.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3300","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T12:17:11Z","timestamp":1752841031000},"source":"Crossref","is-referenced-by-count":0,"title":["Relationship between fractional exhaled nitric oxide, asthma control test, and spirometry measurement in individuals with asthma receiving treatment"],"prefix":"10.4081","volume":"96","author":[{"given":"Arthana","family":"Kanagaraj","sequence":"first","affiliation":[{"name":"Department of Respiratory Therapy, Mahatma Gandhi Medical College and Research Institute, Puducherry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8409-2130","authenticated-orcid":true,"given":"Santhiya","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pajanivel","family":"Ranganadin","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1810-7752","authenticated-orcid":true,"given":"Akila","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Therapy, Mahatma Gandhi Medical College and Research Institute, Puducherry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"59740","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2014.5.0099"},{"key":"59741","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"59742","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1743290"},{"key":"59743","doi-asserted-by":"publisher","DOI":"10.4104\/pcrj.2011.00093"},{"key":"59744","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.04.01"},{"key":"59745","unstructured":"Lamb K, Theodore D, Bhutta BS. Spirometry. Treasure Island (FL): StatPearls Publishing; 2025."},{"key":"59746","unstructured":"Gelb AF, George SC, Silkoff PE, Fraser C, Taylor DR. Fraction of exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to airway inflammation and airflow limitation. Am J Respir Crit Care Med 2006;174:867-71."},{"key":"59747","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"59748","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1498OC"},{"key":"59749","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1427OC"},{"key":"59750","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.023374"},{"key":"59751","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.044"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3300\/2106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3300\/2106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:37Z","timestamp":1790121637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/3300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,7]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2025.3300","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,18]]}}}