{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:58:32Z","timestamp":1790384312275,"version":"4.1.0"},"reference-count":37,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Respiratory problems in acute COVID-19 and post-acute COVID-19 syndrome vary greatly, potentially leading to long-term functional difficulties. Off-label usage of antifibrotics, such as pirfenidone, has emerged as a promising treatment for post-COVID interstitial lung problems. Our study aims to assess clinical and radiological lung abnormalities post-COVID-19 and the effect of antifibrotics on the outcome. A retrospective observational study examined data from 90 COVID-19 patients who completed the follow-up period in the post-COVID clinic at the Chest Department, Kasr El Ainy Hospital, from August 2020 to August 2022. Demographic data, comorbidities, exercise tolerance, and chest computed tomography (CT) results were collected 1 and 6 months after the diagnosis. Initial CT scans (1 month following hospital admission) revealed diffuse ground-glass opacities (87.8%) and reticulations (43.3%). After 6 months, 33.3% were back to normal, 41% had persistent reticulations, 22.2% had ground glass opacities, and 3.3% had bronchiectasis. CT scores improved dramatically after 6 months. No significant link was detected between CT score change and off-label use of pirfenidone. Antifibrotic therapy has a modest effect on post-COVID lung problems. One-third of patients showed reticulations as persistent radiological abnormalities, which could guide future treatment choices.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3301","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T08:59:40Z","timestamp":1749632380000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of antifibrotics on post-COVID-19 lung sequelae"],"prefix":"10.4081","volume":"96","author":[{"given":"Yosri Mohamed Kamel","family":"Akl","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-4210","authenticated-orcid":true,"given":"Youssef Amin","family":"Soliman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabah Ahmed","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afnan Nabil Fatehi","family":"Abdelghaffar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3814-5893","authenticated-orcid":true,"given":"Aml Ibrahim","family":"Bayoumi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"57730","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"57731","doi-asserted-by":"publisher","DOI":"10.18502\/ijph.v49i7.3574"},{"key":"57732","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2021.102058"},{"key":"57733","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02370-4"},{"key":"57734","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.058"},{"key":"57735","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275274"},{"key":"57736","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0194-2021"},{"key":"57737","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061917"},{"key":"57738","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrid.2015.02.003"},{"key":"57739","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_568_21"},{"key":"57740","unstructured":"Masoud H, Elassal G, Hassany M, et al. Management protocol for COVID-19 patients version 1.4\/30th May 2020. In: Coronavirus Disease 2019 (COVID-19), SARS COV2 Management Guideline. Egypt: Ministry of health and population (MOHP); 2020."},{"key":"57741","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06817-6"},{"key":"57742","doi-asserted-by":"publisher","DOI":"10.1089\/andro.2022.0006"},{"key":"57743","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2021211746"},{"key":"57744","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203663"},{"key":"57745","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"57746","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3319"},{"key":"57747","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14300"},{"key":"57748","doi-asserted-by":"publisher","DOI":"10.1186\/s43168-023-00240-3"},{"key":"57749","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24162"},{"key":"57750","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30116-8"},{"key":"57751","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02344-2"},{"key":"57752","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01726-3"},{"key":"57753","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110005"},{"key":"57754","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8980"},{"key":"57755","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"57756","doi-asserted-by":"publisher","DOI":"10.1177\/1753466618800618"},{"key":"57757","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106197"},{"key":"57758","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1750"},{"key":"57759","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.934830"},{"key":"57760","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.a2021.0113"},{"key":"57761","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.925703"},{"key":"57762","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001614"},{"key":"57763","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.IJP_417_20"},{"key":"57764","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23733"},{"key":"57765","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-02947-5"},{"key":"57766","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1143158"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3301\/2087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3301\/2087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:55Z","timestamp":1790380855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/3301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,7]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2025.3301","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,11]]}}}