{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:58:30Z","timestamp":1790384310583,"version":"4.1.0"},"reference-count":40,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Severe asthma exacerbations have high morbidity and mortality. The management can be challenging, and the optimal strategy for patients admitted to the intensive care unit (ICU) with life-threatening and near-fatal asthma has not been fully defined. An interesting area of research is represented by the rescue or compassionate use of biological drugs when all treatments fail, including advanced interventions such as extracorporeal membrane oxygenation. This systematic review analyzes the cases described in the literature and discusses characteristics, treatments, and outcomes of patients who received asthma-approved monoclonal antibodies as rescue therapy following admission to the ICU due to near-fatal asthma exacerbations or status asthmaticus refractory to conventional treatments. A total of 14 studies (13 case reports and 1 case series) were included according to the prespecified inclusion and exclusion criteria. Various monoclonal antibodies were administered, most commonly benralizumab and omalizumab. Treatment was generally initiated within the first week of ICU admission, with nearly half of the patients receiving therapy within 5 days. Further research, including randomized controlled trials, is required to assess if this therapeutic option impacts ICU outcomes, which specific biologics could be used, and their eventual optimal timing and dosage.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3319","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:08:14Z","timestamp":1751450894000},"source":"Crossref","is-referenced-by-count":8,"title":["Potential novel role of asthma biologics as rescue therapy in the intensive care unit for life-threatening asthma exacerbations: a systematic review"],"prefix":"10.4081","volume":"96","author":[{"given":"Lorenzo","family":"Carriera","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Surgery, Catholic University of Sacred Heart, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Valerio","family":"Mari","sequence":"additional","affiliation":[{"name":"San Carlo di Nancy Hospital, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Barone","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Catholic University of Sacred Heart, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ielo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Catholic University of Sacred Heart, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Catholic University of Sacred Heart, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Di Tomasso","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Catholic University of Sacred Heart, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Bezzi","sequence":"additional","affiliation":[{"name":"Pulmonology Department, ASST Spedali Civili, Brescia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Smargiassi","sequence":"additional","affiliation":[{"name":"Pulmonology Division, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Inchingolo","sequence":"additional","affiliation":[{"name":"Pulmonology Division, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Coppola","sequence":"additional","affiliation":[{"name":"Pulmonology Division, San Filippo Neri Hospital, Rome; UniCamillus, Saint Camillus International University of Health Sciences, Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"58862","unstructured":"Global Initiative for Asthma. Global strategy for asthma management and prevention, 2024. Updated May 2024. 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