{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:38:47Z","timestamp":1792543127040,"version":"4.5.0"},"reference-count":24,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Tuberculosis is a global healthcare concern, being the leading infectious cause of mortality by a single infectious agent. India bears the highest burden of tuberculosis. Disease outcome is an important indicator for the successful implementation of the National Program. Risk factors associated with unsuccessful outcomes must be identified, and differential care must be provided to those with risk factors. The study included all pulmonary tuberculosis patients registered from 1st October 2022 to 30th September 2023 at the Directly Observed Therapy Short Course Center, Dr. BR Ambedkar State Institute of Medical Sciences, Mohali, who received treatment. Data were collected from the Nikshay portal retrospectively. Out of 1103, 575 (52.13%) patients were declared cured, whereas 452 (40.97%) were declared treatment completed. A total of 19 (1.72%) pulmonary tuberculosis patients died during treatment, and 57 (5.16%) were declared failures. Advanced age [adjusted odds ratio (AOR) 4.028, 95% confidence interval (CI): 1.368-4.610, p=0.003], people living with HIV (AOR 0.185, 95% CI: 0.031-1.082, p=0.05) and male gender (crude OR 1.611, 95% CI: 0.371-1.006, p=0.050) were associated with poor outcomes. Diabetes, retreatment, microbiological confirmation, and low body mass index were not statistically significant in the study. Age above 45 years, male sex, and HIV co-infection are determinants for unsuccessful treatment outcomes in patients with pulmonary tuberculosis.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3363","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T07:37:12Z","timestamp":1758181032000},"source":"Crossref","is-referenced-by-count":0,"title":["Determinants of unsuccessful treatment outcome of pulmonary tuberculosis under the National Tuberculosis Elimination Program in Mohali district, India"],"prefix":"10.4081","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-0012","authenticated-orcid":true,"given":"Aditi","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Dr. BR Ambedkar State Institute of Medical Sciences, Mohali, Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9767-7740","authenticated-orcid":true,"given":"Vidhu","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, State Tuberculosis Training and Demonstration Center, Government Medical College, Patiala, Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Government Medical College, Patiala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Nadda","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Dr. BR Ambedkar State Institute of Medical Sciences, Mohali, Punjab"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"62750","unstructured":"World Health Organisation. WHO global TB report 2022. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240061729."},{"key":"62751","unstructured":"Holmes KK, Bertozzi S, Bloom BR, et al. Major Infectious Diseases. 3rd ed. Washington (DC): The International Bank for Reconstruction and Development\/The World Bank; 2017."},{"key":"62752","unstructured":"World Health Organization. End TB strategy: global strategy and targets for tuberculosis prevention, care and control after 2015. Available from: https:\/\/cdn.who.int\/media\/docs\/default-source\/documents\/tuberculosis\/end-tb-strategy-information-sheet8817f818-feaa-49ac-b26a-92c5b9dca034.pdf."},{"key":"62753","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58080-0"},{"key":"62754","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2024.101505"},{"key":"62755","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2015.20.247.3345"},{"key":"62756","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00038"},{"key":"62757","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S413272"},{"key":"62758","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0273069"},{"key":"62759","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac541"},{"key":"62760","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182312827"},{"key":"62761","doi-asserted-by":"publisher","DOI":"10.1080\/17441692.2024.2307979"},{"key":"62762","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3019-7"},{"key":"62763","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13720"},{"key":"62764","unstructured":"Population census. Mohali (Sahibzada Ajit Singh Nagar) District - Population 2011-2025. Available from: https:\/\/www.census2011.co.in\/census\/district\/605-mohali.html."},{"key":"62765","unstructured":"Central Tuberculosis Division. India TB report 2022. Available from: https:\/\/tbcindia.mohfw.gov.in\/2023\/06\/06\/india-tb-report-2022\/."},{"key":"62766","unstructured":"Central Tuberculosis Division. Technical and operational guidelines (TOG) for TB control in India 2016 \u2013 chapter 4: treatment of TB. Available from: https:\/\/tbcindia.mohfw.gov.in\/technical-and-operational-guidelines-for-tb-control-in- india-2016\/."},{"key":"62767","unstructured":"World Health Organization. Definitions and reporting framework for tuberculosis \u2013 2013 revision: updated December 2014 and January 2020. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241505345."},{"key":"62768","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1503219"},{"key":"62769","unstructured":"Loscalzo J, Fauci A, Kasper D. Harrison's principles of internal medicine, 21st ed. New York, NY, USA: McGraw-Hill Education; 2022."},{"key":"62770","doi-asserted-by":"publisher","DOI":"10.1258\/td.2011.110421"},{"key":"62771","unstructured":"Sharma SK, Soneja M, Prasad KT, Ranjan S. Clinical profile & predictors of poor outcome of adult HIV-tuberculosis patients in a tertiary care centre in north India. Indian J Med Res 2014;139:154-60."},{"key":"62772","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.22.0470"},{"key":"62773","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.22.0448"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3363\/2137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3363\/2137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:02:54Z","timestamp":1792540974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/3363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,7]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2025.3363","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}