{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:49:28Z","timestamp":1764841768380,"version":"3.46.0"},"reference-count":28,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Tuberculosis has remained an intractable challenge for mankind. The Cascade of Care approach is adopted, emphasizing early detection of latent tuberculosis infections through screening and primordial prevention of disease holistically. Currently available tests include the tuberculin skin test (TST) and interferon-\u03b3 release assays (IGRA). Our study aims at identifying the adequacy of prevailing operational knowledge about these tests amongst the interns and postgraduates who form the future medical fraternity. We conducted a prospective questionnaire-based study among interns and postgraduates. Further data compilation was done using Microsoft Excel. Comparison between groups was done using appropriate statistical tests. In our study conducted on 196 participants, we found that 53.41% of the total questions were answered rightly. The correct responses for the questions on TST were 65.29%, while for IGRA, they were 33.45%. Our study discloses the problem of a significant gap in operational knowledge about the screening tests, silently delaying the achievement of the vision, mission, and goals of the National Tuberculosis Elimination Program. India is both committed and concerned: as a solution, there is an urgent need to address this through continued medical education and periodic training workshops by utilizing the existing resources and allocations.<\/jats:p>","DOI":"10.4081\/monaldi.2025.3590","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:43:41Z","timestamp":1764841421000},"source":"Crossref","is-referenced-by-count":0,"title":["Identifying the gap in operational knowledge regarding the tuberculin skin test and interferon-\u03b3 release assay among interns and postgraduates of a medical college"],"prefix":"10.4081","author":[{"given":"Narayana","family":"Holla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preethiraj","family":"Ballal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandakishore","family":"KS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2913-6119","authenticated-orcid":false,"given":"Anirudha","family":"Katipalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supreetha","family":"T","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dixith","family":"T","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vignesh","family":"TM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushmitha","family":"Sudeesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"68306","unstructured":"World Health Organization. Global tuberculosis report 2021. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240037021."},{"key":"68307","unstructured":"Central TB Division, Ministry of Health and Family Welfare. India TB report 2024 . Available from: https:\/\/tbcindia.mohfw.gov.in\/wp-content\/uploads\/2024\/10\/TB-Report_for-Web_08_10-2024-1.pdf."},{"key":"68308","unstructured":"World Health Organization. WHO consolidated guidelines on tuberculosis. Module 1: prevention. Tuberculosis preventive treatment. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240001503."},{"key":"68309","doi-asserted-by":"crossref","unstructured":"Houben RMGJ, Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med 2016;13:e1002152.","DOI":"10.1371\/journal.pmed.1002152"},{"key":"68310","doi-asserted-by":"crossref","unstructured":"Behr MA, Edelstein PH, Ramakrishnan L. Revisiting the timetable of tuberculosis. BMJ 2018;362:k2738.","DOI":"10.1136\/bmj.k2738"},{"key":"68311","unstructured":"Rieder HL, Chiang CY, Gie R, Enarson DA. Crofton\u2019s clinical tuberculosis. New York, NY, USA: MacMillan; 2009."},{"key":"68312","unstructured":"Central Tuberculosis Division, Ministry of Health and Family Welfare. The guidelines on programmatic management of tuberculosis preventive treatment in India. Available from: https:\/\/tbcindia.mohfw.gov.in\/wp-content\/uploads\/2023\/05\/Guidelines-for-Programmatic-Management-of-Tuberculosis-Preventive-Treatment-in-India.pdf"},{"key":"68313","doi-asserted-by":"crossref","unstructured":"Alsdurf H, Hill PC, Matteelli A, et al. The cascade of care in diagnosis and treatment of latent tuberculosis infection: a systematic review and meta-analysis. Lancet Infect Dis 2016;16:1269-78.","DOI":"10.1016\/S1473-3099(16)30216-X"},{"key":"68314","unstructured":"L\u00f6nnroth K, Migliori GB, Abubakar I, et al. Towards tuberculosis elimination: an action framework for low-incidence countries. Eur Respir J 2015 31;45:928-52."},{"key":"68315","doi-asserted-by":"crossref","unstructured":"Paradkar M, Padmapriyadarsini C, Jain D, et al. Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India. PLoS One 2020;15:e0236743.","DOI":"10.1371\/journal.pone.0236743"},{"key":"68316","doi-asserted-by":"crossref","unstructured":"Martinson NA, Barnes GL, Moulton LH, et al. New regimens to prevent tuberculosis in adults with HIV infection. N Engl J Med 2011;365:11-20.","DOI":"10.1056\/NEJMoa1005136"},{"key":"68317","doi-asserted-by":"crossref","unstructured":"Nayak S, Acharjya B. Mantoux test and its interpretation. Indian Dermatol Online J 2012;3:2-6.","DOI":"10.4103\/2229-5178.93479"},{"key":"68318","doi-asserted-by":"crossref","unstructured":"Pai M, Denkinger CM, Kik SV, et al. Gamma Interferon Release Assays for Detection of Mycobacterium tuberculosis Infection. Clin Microbiol Rev 2014;27:3-20.","DOI":"10.1128\/CMR.00034-13"},{"key":"68319","unstructured":"QIAGEN. QuantiFERON-TB Gold Plus \u2013 world's leading tuberculosis blood test. Available from: https:\/\/quantiferon.com\/jp\/cd\/patient-resources\/quantiferon-tb-gold-2\/."},{"key":"68320","unstructured":"CDC. Clinical testing guidance for tuberculosis: interferon gamma release assay. 2024 Available from: https:\/\/www.cdc.gov\/tb\/hcp\/testing-diagnosis\/interferon-gamma-release-assay.html."},{"key":"68321","unstructured":"Revvity. T-SPOT Technology (ELISPOT). Available from: https:\/\/www.tspot.com\/why-the-t-spot-tb-test\/."},{"key":"68322","unstructured":"MyLab. Cy-Tb - the next gen test for latent TB detection. Available from: https:\/\/mylabglobal.com\/cy-tb\/."},{"key":"68323","doi-asserted-by":"crossref","unstructured":"Matteelli A, Lovatti S, Sforza A, Rossi L. Programmatic management of tuberculosis preventive therapy: past, present, future. Int J Infect Dis 2023;130:S43-6.","DOI":"10.1016\/j.ijid.2023.02.016"},{"key":"68324","doi-asserted-by":"crossref","unstructured":"Gupta A, Chandra E, Anand S, et al. Latent tuberculosis diagnostics: current scenario and review. Monaldi Arch Chest Dis 2025;95:2984.","DOI":"10.4081\/monaldi.2024.2984"},{"key":"68325","doi-asserted-by":"crossref","unstructured":"Arinaminpathy N, Mandal S, Bhatia V, et al. Strategies for ending tuberculosis in the South-East Asian Region: A modelling approach. Indian J Med Res 2019;149:517-27.","DOI":"10.4103\/ijmr.IJMR_1901_18"},{"key":"68326","doi-asserted-by":"crossref","unstructured":"Haritsa K, Sangeetha P, Lakshminarayana SA, et al. Impact of sensitisation programme on screening tests for latent tuberculosis infection among health-care workers: a questionnaire-based study. J Clin Sci Res 2023;12:97.","DOI":"10.4103\/jcsr.jcsr_78_22"},{"key":"68327","unstructured":"KS N, Ballal P, T S, et al. Outcome ofsensitization programme on Latent Tuberculosis Infection screening tests among interns \u2013 a questionnaire\u2011based study. Int J Med 2024 24;8:1-7."},{"key":"68328","doi-asserted-by":"crossref","unstructured":"Holla Vn, Borker S, Salelkar S, Shashikala N. Impact of National Tuberculosis Elimination Program sensitization workshop on health-care workers in a Medical College and Hospital in Karnataka, India. MRIMS J Health Sci 2020;8:79.","DOI":"10.4103\/mjhs.mjhs_17_20"},{"key":"68329","unstructured":"Aggarwal R, Sahu D, Manuja AK, Mehera S. Awareness about tuberculosis andRNTCP-DOTS guidelines among nurses working in a rural medical college in Haryana. Int J Res Health Sci 2017;5:8-12."},{"key":"68330","doi-asserted-by":"crossref","unstructured":"Berg-Johnsen A, H\u00e5dem SO, Tamrakar D, Harstad I. A questionnaire of knowledge, attitude and practices on tuberculosis among medical interns in Nepal. J Clin Tuberc Other Mycobact Dis 2020;20:100173.","DOI":"10.1016\/j.jctube.2020.100173"},{"key":"68331","doi-asserted-by":"crossref","unstructured":"Shrestha A, Bhattarai D, Thapa B, et al. Health care workers\u2019 knowledge, attitudes and practices on tuberculosis infection control, Nepal. BMC Infect Dis 2017;17:724.","DOI":"10.1186\/s12879-017-2828-4"},{"key":"68332","unstructured":"Singla N, Sharma PP, Singla R, Jain RC. Survey of knowledge, attitudes and practices for tuberculosis among general practitioners in Delhi, India. Int J Tuberc Lung Dis 1998;2:384-9."},{"key":"68333","unstructured":"Bhat S, Singal N, Aggarwal CS, Jain RC. Knowledge, attitudes and practices of newly diagnosed sputum positive cases of pulmonary tuberculosis. J Commun Dis 1999;31:247-52."}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3590\/2163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3590\/2164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3590\/2163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:43:46Z","timestamp":1764841426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/3590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":28,"URL":"https:\/\/doi.org\/10.4081\/monaldi.2025.3590","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,4]]}}}