{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:25:36Z","timestamp":1788337536228,"version":"build-2803163510"},"reference-count":24,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Colchicine is an anti-inflammatory drug that has emerged as a potential treatment option following myocardial infarction (MI). This meta-analysis assesses the efficacy and safety of colchicine in patients following an MI. A comprehensive literature search was performed using the Cochrane Library, ClinicalTrials.gov, Embase, and MEDLINE, covering studies from their inception to December 2025. RevMan was used to perform a random-effects meta-analysis, and forest plots were used to visualize pooled estimates. The Mantel-Haenszel method was applied to analyze dichotomous outcomes. Nine randomized control trials (RCTs) were included in this meta-analysis, including 13,834 patients. The analysis revealed that there was no statistically significant difference between colchicine and placebo groups in all-cause mortality [relative risk (RR)=0.93, confidence interval (CI)=0.78-1.11], cardiac death (RR=0.95, CI=0.73-1.22), MI (RR=0.82, CI=0.67-1.00), stroke (RR=0.64, CI=0.26-1.58), adverse events (RR=1.01, CI=0.85-1.21),\u00a0 serious adverse events (RR=0.96, CI=0.87-1.05), serious gastrointestinal adverse events (RR=1.35, CI=0.94-1.95), and serious infections (RR=1.00, CI=0.62-1.62). However, there was an increased risk of diarrhea in people with colchicine compared to the placebo (RR=2.12, CI=1.35-3.32). This meta-analysis demonstrates that colchicine following an MI does not have a significant impact on cardiovascular events or major adverse events other than an increased risk of diarrhea. There is a need for more comprehensive RCTs with longer follow-up times to fully comprehend the potential cardiovascular benefits of colchicine.<\/jats:p>","DOI":"10.4081\/monaldi.2026.3897","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:10:25Z","timestamp":1788336625000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of colchicine in patients with myocardial infarction: a systematic review and meta-analysis"],"prefix":"10.4081","author":[{"given":"Muhammad Furqan","family":"Saleem","sequence":"first","affiliation":[{"name":"Department of Cardiology, Loma Linda University Medical Center, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nishtar Medical University, Multan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mekki","sequence":"additional","affiliation":[{"name":"Department of Medicine, Alshifa Hospital, Gaza"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Siddique","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faisalabad Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usama","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faisalabad Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaudhry Bilal","family":"Rauf","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Poonch Medical College, Rawalakot"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaudhary Hammad","family":"Jamil","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Punjab Institute of Cardiology, Lahore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azaz Ali","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Saidu Teaching Hospital, Swat"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usman","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Medicine, Geisinger Health System, Wilkes-Barre, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Illinois College of Medicine-Peoria, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ebad Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rawalpindi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huzaifa Ahmad","family":"Cheema","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Edward Medical University, Lahore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilawal","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"National Heart & Lung Institute, Imperial College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"86215","unstructured":"CDC. NHANES 2015-2016 overview. Available from: https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/continuousnhanes\/overview.aspx?BeginYear=2015"},{"key":"86216","doi-asserted-by":"crossref","unstructured":"Ridker PM. How common is residual inflammatory risk? Circ Res 2017;120:617-9.","DOI":"10.1161\/CIRCRESAHA.116.310527"},{"key":"86217","doi-asserted-by":"crossref","unstructured":"Ridker PM, Bhatt DL, Pradhan AD, et al. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet 2023;401:1293-301.","DOI":"10.1016\/S0140-6736(23)00215-5"},{"key":"86218","doi-asserted-by":"crossref","unstructured":"Zhang FS, He QZ, Qin CH, et al. Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review. Acta Pharmacol Sin 2022;43:2173-90.","DOI":"10.1038\/s41401-021-00835-w"},{"key":"86219","doi-asserted-by":"crossref","unstructured":"Zhang CY, Liu S, Sui YX, Yang M. Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome: from action mechanism to therapeutic target in clinical trials. World J Gastrointest Oncol 2025;17:100094.","DOI":"10.4251\/wjgo.v17.i2.100094"},{"key":"86220","doi-asserted-by":"crossref","unstructured":"Adler Y, Charron P, Imazio M, et al. 2015 ESC guidelines for the diagnosis and management of pericardial diseases: the Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2015;36:2921-64.","DOI":"10.1093\/eurheartj\/ehv318"},{"key":"86221","doi-asserted-by":"crossref","unstructured":"Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL. Low-dose colchicine for secondary prevention of cardiovascular disease. J Am Coll Cardiol 2013;61:404-10.","DOI":"10.1016\/j.jacc.2012.10.027"},{"key":"86222","doi-asserted-by":"crossref","unstructured":"Younas A, Awan Z, Khan T, et al. The effect of colchicine on myocardial infarction: An updated systematic review and meta-analysis of randomized controlled trials. Curr Probl Cardiol 2025;50:102878.","DOI":"10.1016\/j.cpcardiol.2024.102878"},{"key":"86223","doi-asserted-by":"crossref","unstructured":"Jolly SS, d\u2019Entremont MA, Lee SF, et al. Colchicine in acute myocardial infarction. N Engl J Med 2025;392:633-42.","DOI":"10.1056\/NEJMoa2405922"},{"key":"86224","doi-asserted-by":"crossref","unstructured":"Akodad M, Lattuca B, Nagot N, et al. COLIN trial: value of colchicine in the treatment of patients with acute myocardial infarction and inflammatory response. Arch Cardiovasc Dis 2017;110:395-402.","DOI":"10.1016\/j.acvd.2016.10.004"},{"key":"86225","doi-asserted-by":"crossref","unstructured":"Akrami M, Izadpanah P, Bazrafshan M, et al. Effects of colchicine on major adverse cardiac events in next 6-month period after acute coronary syndrome occurrence; a randomized placebo-control trial. BMC Cardiovasc Disord 2021;21:583.","DOI":"10.1186\/s12872-021-02393-9"},{"key":"86226","doi-asserted-by":"crossref","unstructured":"Bouleti C, Viscogliosi S, Bresson D, et al. Colchicine in acute myocardial infarction: cardiovascular events at 1-year follow up. Open Heart 2024;11:e002474.","DOI":"10.1136\/openhrt-2023-002474"},{"key":"86227","doi-asserted-by":"crossref","unstructured":"Deftereos S, Giannopoulos G, Angelidis C, et al. Anti-inflammatory treatment with colchicine in acute myocardial infarction. Circulation 2015;132:1395-403.","DOI":"10.1161\/CIRCULATIONAHA.115.017611"},{"key":"86228","doi-asserted-by":"crossref","unstructured":"Hennessy T, Soh L, Bowman M, et al. The low dose colchicine after myocardial infarction (LoDoCo-MI) study: a pilot randomized placebo controlled trial of colchicine following acute myocardial infarction. Am Heart J 2019;215:62-9.","DOI":"10.1016\/j.ahj.2019.06.003"},{"key":"86229","doi-asserted-by":"crossref","unstructured":"Mewton N, Roubille F, Bresson D, et al. Effect of colchicine on myocardial injury in acute myocardial infarction. Circulation 2021;144:859-69.","DOI":"10.1161\/CIRCULATIONAHA.121.056177"},{"key":"86230","doi-asserted-by":"crossref","unstructured":"Roubille F, Bouabdallaoui N, Kouz S, et al. Low-dose colchicine in patients with type 2 diabetes and recent myocardial infarction in the colchicine cardiovascular outcomes Trial (COLCOT). Diabetes Care 2024;47:467-70.","DOI":"10.2337\/dc23-1825"},{"key":"86231","doi-asserted-by":"crossref","unstructured":"Tardif JC, Kouz S, Waters DD, et al. Efficacy and safety of low-dose colchicine after myocardial infarction. N Engl J Med 2019;381:2497-505.","DOI":"10.1056\/NEJMoa1912388"},{"key":"86232","doi-asserted-by":"crossref","unstructured":"Chen T, Liu G, Yu B. Colchicine for coronary artery disease: a review. Front Cardiovasc Med 2022;9:892588.","DOI":"10.3389\/fcvm.2022.892588"},{"key":"86233","doi-asserted-by":"crossref","unstructured":"Park HJ. Anti-inflammatory effects of colchicine on coronary artery disease. Cardiovasc Prev Pharmacother 2022;4:7-12.","DOI":"10.36011\/cpp.2022.4.e5"},{"key":"86234","doi-asserted-by":"crossref","unstructured":"Yu M, Yang Y, Dong SL, et al. Effect of colchicine on coronary plaque stability in acute coronary syndrome as assessed by optical coherence tomography: the COLOCT randomized clinical trial. Circulation 2024;150:981-93.","DOI":"10.1161\/CIRCULATIONAHA.124.069808"},{"key":"86235","doi-asserted-by":"crossref","unstructured":"Shah B, Allen N, Harchandani B, et al. Effect of colchicine on platelet-platelet and platelet-leukocyte interactions: a pilot study in healthy subjects. Inflammation 2016;39:182-9.","DOI":"10.1007\/s10753-015-0237-7"},{"key":"86236","doi-asserted-by":"crossref","unstructured":"Diaz-Arocutipa C, Benites-Meza JK, Chambergo-Michilot D, et al. Efficacy and Safety of colchicine in post-acute myocardial infarction patients: a systematic review and meta-analysis of randomized controlled trials. Front Cardiovasc Med 2021;8:676771.","DOI":"10.3389\/fcvm.2021.676771"},{"key":"86237","doi-asserted-by":"crossref","unstructured":"Leung YY, Hui LLY, Kraus VB. Colchicine --- update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum 2015;45:341-50.","DOI":"10.1016\/j.semarthrit.2015.06.013"},{"key":"86238","unstructured":"Sadiq NM, Robinson KJ, Terrell JM. Colchicine. 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