{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:47:42Z","timestamp":1782899262095,"version":"3.54.5"},"reference-count":14,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Pulmonary tuberculosis often results in permanent lung damage, such as fibrosis, bronchiectasis, and emphysema, despite a successful microbiological cure. These structural changes lead to post-tuberculosis lung disease (PTLD), which is characterized by chronic respiratory symptoms and impaired lung function. This study aimed to evaluate functional and radiological impairments in patients after completion of anti-tubercular therapy to understand the long-term impact of tuberculosis on respiratory health. This prospective study evaluated 175 adults within 1 year of completing anti-tubercular therapy to assess the prevalence of PTLD. Results revealed spirometric abnormalities in 57.1% of participants, predominantly restrictive patterns (30.3%), followed by obstructive defects (16.6%) and Preserved Ratio Impaired Spirometry or PRISm (10.3%). Sputum smear positive status at diagnosis strongly predicted obstructive disease and severe structural damage. Notably, this impairment affected a young, non-smoking cohort and was largely irreversible. The study concludes that microbiological cure does not equate to respiratory health, highlighting the necessity of integrating assessment of comprehensive respiratory system evaluation and routine spirometry at treatment completion to manage long-term morbidity.<\/jats:p>","DOI":"10.4081\/monaldi.2026.3904","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:02:53Z","timestamp":1782896573000},"source":"Crossref","is-referenced-by-count":0,"title":["Spirometry after treatment completion for pulmonary tuberculosis \u2013 a necessity?"],"prefix":"10.4081","author":[{"given":"Siddhartha","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Ajai","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen K","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kislay","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritwik","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"81752","unstructured":"Ministry of Health and Family Welfare. India TB report 2024. Available from: https:\/\/tbcindia.mohfw.gov.in\/wp-content\/uploads\/2024\/10\/TB-Report_for-Web_08_10-2024-1.pdf."},{"key":"81753","doi-asserted-by":"crossref","unstructured":"Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Respir Rev 2018;27:170077.","DOI":"10.1183\/16000617.0077-2017"},{"key":"81754","doi-asserted-by":"crossref","unstructured":"Allwood BW, Byrne A, Meghji J, et al. Post-tuberculosis lung disease: clinical review of an under-recognised global challenge. Respiration 2021;100:751-63.","DOI":"10.1159\/000512531"},{"key":"81755","doi-asserted-by":"crossref","unstructured":"Cupido G, G\u00fcnther G. Post tuberculosis lung disease and tuberculosis sequelae: a narrative review. Indian J Tuberc 2024;71:64-72.","DOI":"10.1016\/j.ijtb.2023.04.001"},{"key":"81756","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD 2026 report. Available from: https:\/\/goldcopd.org\/wp-content\/uploads\/2026\/01\/GOLD-REPORT-2026-v1.3-8Dec2025_WMV2.pdf."},{"key":"81757","doi-asserted-by":"crossref","unstructured":"Byrne A, Al-Hindawi Y, Plit M, et al. The prevalence and pattern of post tuberculosis lung disease including pulmonary hypertension from an Australian TB service; a single-centre, retrospective cohort study. BMC Pulm Med 2025;25:84.","DOI":"10.1186\/s12890-025-03549-5"},{"key":"81758","doi-asserted-by":"crossref","unstructured":"Manji M, Shayo G, Mamuya S, et al. Lung functions among patients with pulmonary tuberculosis in Dar es Salaam - a cross-sectional study. BMC Pulm Med 2016;16:58.","DOI":"10.1186\/s12890-016-0213-5"},{"key":"81759","doi-asserted-by":"crossref","unstructured":"Patil S, Patil R, Jadhav A. Pulmonary functions\u2019 assessment in post-tuberculosis cases by spirometry: obstructive pattern is predominant and needs cautious evaluation in all treated cases irrespective of symptoms. Int J Mycobacteriol 2018;7:128-33.","DOI":"10.4103\/ijmy.ijmy_56_18"},{"key":"81760","doi-asserted-by":"crossref","unstructured":"Chakravarti C, Patel KH, Cheguri VR, Patel BM. Clinical, radiological and spirometric analysis of treated tuberculosis patients-a cross-sectional study. J Clin Diagn Res 2023;17:OC17-20.","DOI":"10.7860\/JCDR\/2023\/61146.17641"},{"key":"81761","doi-asserted-by":"crossref","unstructured":"Govindaswamy S, Jaganathan V, Sathick Batcha AK, et al. Impact of post-pulmonary tuberculosis sequelae and its management in a tertiary care facility in South India. Indian J Tuberc 2025;72:S75-9.","DOI":"10.1016\/j.ijtb.2024.10.008"},{"key":"81762","doi-asserted-by":"crossref","unstructured":"Pandey A, Agrawal R, Agarwal R, et al. Assessment of symptomatic post tuberculosis patients by spirometry and chest X ray. Int J Contemp Med Res 2020;7:A1-6.","DOI":"10.21276\/ijcmr.2020.7.1.21"},{"key":"81763","doi-asserted-by":"crossref","unstructured":"Menezes AMB, Hallal PC, Perez-Padilla R, et al. Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America. Eur Respir J 2007;30:1180-5.","DOI":"10.1183\/09031936.00083507"},{"key":"81764","doi-asserted-by":"crossref","unstructured":"Aggarwal D, Gupta A, Janmeja AK, Bhardwaj M. Evaluation of tuberculosis-associated chronic obstructive pulmonary disease at a tertiary care hospital: a case-control study. Lung India 2017;34:415-9.","DOI":"10.4103\/lungindia.lungindia_522_16"},{"key":"81765","doi-asserted-by":"crossref","unstructured":"Woldesemayat EM, Vera JH, Tanner C, et al. Lung function of tuberculosis patients after completion of treatment in Sidama, South Ethiopia. Front Med 2025;12:1451861.","DOI":"10.3389\/fmed.2025.1451861"}],"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3904\/2237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/download\/3904\/2237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:04:02Z","timestamp":1782896642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.monaldi-archives.org\/macd\/article\/view\/3904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":14,"URL":"https:\/\/doi.org\/10.4081\/monaldi.2026.3904","relation":{},"ISSN":["2532-5264","1122-0643"],"issn-type":[{"value":"2532-5264","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}