{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:31:00Z","timestamp":1773214260401,"version":"3.50.1"},"reference-count":35,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Long-term consequences of viral pneumonia on lung function depend on virus-specific tissue injury. Persistent impairment of alveolar-blood gas transport has been described after SARS-CoV-2 pneumonia but has not been investigated following respiratory syncytial virus (RSV) pneumonia. Possible long-term effects of these two viral infections were never compared after their clinical resolution in terms of lung physiology. The aim of this paper was to compare long-term sequelae of RSV and SARS-CoV-2 pneumonia on lung function and blood gas transport. Adults (&gt;18 years) with previous RSV or SARS-CoV-2 pneumonia were investigated after complete computed tomography scan resolution. Collected variables included demographics, body mass index, hemoglobin, SpO\u2082, modified British Medical Research Council dyspnea score, spirometry, diffusing capacity [diffusing capacity for carbon oxide (DLCO), carbon monoxide transfer coefficient (KCO)], single-breath diffusing capacity for nitric oxide (DLNO) and DLCO, DLNO\/DLCO ratio, and lung capillary blood volume (Vc). 38 post-SARS-CoV-2 and 37 post-RSV patients were studied. Groups were comparable and showed similar spirometric values. Compared with RSV, SARS-CoV-2 patients had significantly lower SpO\u2082, DLCO, and KCO (p&lt;0.01). Vc was markedly reduced (p&lt;0.001), with a corresponding increase in the DLNO\/DLCO ratio (p&lt;0.001). Only post-RSV patients were dyspnea-free. In conclusion, viral pneumonia may cause long-lasting lung function impairment depending on virus-specific tissue damage. Unlike RSV, SARS-CoV-2 pneumonia induces a persistent reduction of lung Vc, leading to impaired gas exchange despite radiological resolution.<\/jats:p>","DOI":"10.4081\/monaldi.2026.3911","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:09:27Z","timestamp":1773050967000},"source":"Crossref","is-referenced-by-count":0,"title":["Pneumonia due to respiratory syncytial virus does not cause long-lasting disorders in respiratory gas transport after clinical resolution in adults. Comparison &lt;i&gt;vs&lt;\/i&gt;. SARS-CoV-2 pneumonia"],"prefix":"10.4081","author":[{"given":"Roberto W.","family":"Dal Negro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Turco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Povero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"74060","doi-asserted-by":"crossref","unstructured":"Widmer K, Zhu Y, Williams JV, et al. Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. J Infect Dis 2012;206:56-62.","DOI":"10.1093\/infdis\/jis309"},{"key":"74061","doi-asserted-by":"crossref","unstructured":"Wright AL, Taussig LM, Ray CG, et al. The Tucson Children\u2019s Respiratory Study. II. 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