{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:19:30Z","timestamp":1774844370633,"version":"3.50.1"},"reference-count":16,"publisher":"Mattioli1885","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Multidis Res Med"],"abstract":"<jats:p>Background: Exacerbations are pivotal events in the natural history of patients with non-cystic fibrosis bronchiectasis (NCFB), since they have a negative impact on the functional evolution of these individuals. The daily symptoms of\u00a0patients with NCFB show great variability, which negatively affects their self-perception of symptoms and exacerbations. The aim of this study was to identify daily symptoms in patients with NCFB, and to investigate whether there\u00a0is a correlation between the frequency of self-reported exacerbations and events defined according to the criteria established in the literature to define exacerbation in bronchiectasis.Methods: This observational and prospective study was carried out in outpatient clinics of a Brazilian public university hospital. Over 24 weeks, patients completed a diary in which daily symptoms, self-reported exacerbations, and demands for medical care for respiratory symptoms were recorded. The instruments used (diary and symptom scores ranging from 0 to 12) were developed by the researchers. The participants also answered questionnaires mMRC,\u00a0Leicester\u2019s, and St. George's Respiratory (SGRQ).Results: Twenty-eight patients returned the diary, their mean age was 54 years, and 50% out of them were classifiedas mild by the FACED score. Cough (64%) and expectoration (62%) were the most frequent symptoms. Correlations were found between the stability score and the mMRC (r=0.4727, p=0.011) and SGRQ (r=0.6748, p&lt;0.0001) questionnaires. The number of self-perceived exacerbations (24) was significantly lower than exacerbations using the exacerbation consensus (63) (p&lt;0.01). Additionally, no correlation was found between these two criteria.\u00a0Conclusions: There was great variability of symptoms among the individuals sampled, and even for the same individual, over time. Patients had low self-perception of exacerbations, which suggests that strategies aimed at improving\u00a0this self-perception may contribute to the early detection of exacerbations.<\/jats:p>","DOI":"10.4081\/mrm.2022.859","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T08:46:08Z","timestamp":1669884368000},"source":"Crossref","is-referenced-by-count":1,"title":["Monitoring daily symptoms and (self-reported) exacerbations in patients with bronchiectasis: a prospective study"],"prefix":"10.5826","volume":"17","author":[{"given":"Jessica de","family":"Campos Medeiros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1dria Cristina","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"Corso Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"6730","doi-asserted-by":"crossref","unstructured":"Chalmers JD, Aliberti S, Filonenko A, Shteinberg M, Goeminne PC, Hill AT, et al. Characterization of the \"frequent exacerbator phenotype\" in bronchiectasis. Am J Respir Crit Care Med 2018;197:1410-20.","DOI":"10.1164\/rccm.201711-2202OC"},{"key":"6731","doi-asserted-by":"crossref","unstructured":"Martinez-Garcia MA, Athanazio RA, Gir\u00f3n R, M\u00e1iz-Carro L, de la Rosa D, Olveira C, et al. Predicting high risk of exacerbations in bronchiectasis: the E-FACED score. Int J Chron Obstruct Pulmon Dis 2017;12:275-84.","DOI":"10.2147\/COPD.S121943"},{"key":"6732","doi-asserted-by":"crossref","unstructured":"Hill AT, Haworth CS, Aliberti S, Barker A, Blasi F, Boersma W, et al. Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research. Eur Respir J 2017;49:1700051.","DOI":"10.1183\/13993003.00051-2017"},{"key":"6733","doi-asserted-by":"crossref","unstructured":"Chawla K, Vishwanath S, Manu MK, Lazer B. Influence of pseudomonas aeruginosa on exacerbation in patients with bronchiectasis. J Glob Infect Dis 2015;7:18-22.","DOI":"10.4103\/0974-777X.150885"},{"key":"6734","doi-asserted-by":"crossref","unstructured":"Goeminne P, Dupont L. Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. Postgrad Med J 2010;86:493-501.","DOI":"10.1136\/pgmj.2009.091041"},{"key":"6735","doi-asserted-by":"crossref","unstructured":"Nicotra MB, Rivera M, Dale AM, Shepherd R, Carter R. Clinical, pathophysiologic, and microbiologic characterization of bronchiectasis in an aging cohort. Chest 1995;108:955-61.","DOI":"10.1378\/chest.108.4.955"},{"key":"6736","doi-asserted-by":"crossref","unstructured":"Palwatwichai A, Chaoprasong C, Vattanathum A, Wongsa A, Jatakanon A. Clinical, laboratory findings and microbiologic characterization of bronchiectasis in Thai patients. Respirology 2002;7:63-6.","DOI":"10.1046\/j.1440-1843.2002.00367.x"},{"key":"6737","doi-asserted-by":"crossref","unstructured":"Spinou A, Fragkos KC, Lee KK, et al. The validity of health-related quality of life questionnaires in bronchiectasis: a systematic review and meta-analysis. Thorax 2016;71:683-94.","DOI":"10.1136\/thoraxjnl-2015-207315"},{"key":"6738","doi-asserted-by":"crossref","unstructured":"Goeminne P, Dupont L. Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century. Postgrad Med J 2010;86:493-501.","DOI":"10.1136\/pgmj.2009.091041"},{"key":"6739","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Garc\u00eda M\u00c1, de Gracia J, Vendrell Relat M, et al. Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score. Eur Respir J 2014;43:1357-67.","DOI":"10.1183\/09031936.00026313"},{"key":"6740","doi-asserted-by":"crossref","unstructured":"Artaraz A, Crichton ML, Finch S, et al. Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST). Respir Res 2020;21:18.","DOI":"10.1186\/s12931-019-1272-y"},{"key":"6741","doi-asserted-by":"crossref","unstructured":"Langsetmo L, Platt RW, Ernst P, Bourbeau J. Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort. Am J Respir Crit Care Med 2008;177:396-401.","DOI":"10.1164\/rccm.200708-1290OC"},{"key":"6742","doi-asserted-by":"crossref","unstructured":"Omachi TA, Sarkar U, Yelin EH, Blanc PD, Katz PP. Lower health literacy is associated with poorer health status and outcomes in chronic obstructive pulmonary disease. J Gen Intern Med 2013;28:74-81.","DOI":"10.1007\/s11606-012-2177-3"},{"key":"6743","doi-asserted-by":"crossref","unstructured":"Rocha PC, Lemos SMA. Conceptual aspects and factors associated with functional health literacy: a literary review. CEFAC 2016;18:214-25.","DOI":"10.1590\/1982-021620161819615"},{"key":"6744","doi-asserted-by":"crossref","unstructured":"Sun X, Shi Y, Zeng Q, Wang Y, Du W, Wei N, et al. Determinants of health literacy and health behavior regarding infectious respiratory diseases: a pathway model. BMC Public Health 2013;13:261.","DOI":"10.1186\/1471-2458-13-261"},{"key":"6745","doi-asserted-by":"crossref","unstructured":"Korpershoek Y, Bruins Slot J, Effing T, Schuurmans M, Trappenburg J. Self-management behaviors to reduce exacerbation impact in COPD patients: a Delphi study. 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