{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:41:53Z","timestamp":1792078913532,"version":"4.4.0"},"reference-count":0,"publisher":"MDPI AG","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol Int"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the largest cause of dementia, affecting 35.6 million people in 2010. Amyloid precursor protein, presenilin 1 and presenilin 2 mutations are known to cause familial early-onset AD, whereas apolipoprotein E (APOE) \u03b54 is a susceptibility gene for late-onset AD. The genes for phosphatidylinositol- binding clathrin assembly protein, clusterin and complement receptor 1 have recently been described by genome-wide association studies as potential risk factors for lateonset AD. Also, a genome association study using single neucleotide polymorphisms has identified an association of neuronal sortilin related receptor and late-onset AD. Gene testing, and also predictive gene testing, may be of benefit in suspected familial early-onset AD however it adds little to the diagnosis of lateonset AD and does not alter the treatment. We do not recommend APOE \u03b54 genotyping.<\/jats:p>","DOI":"10.4081\/ni.2011.e1","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T14:24:50Z","timestamp":1302099890000},"page":"1","source":"Crossref","is-referenced-by-count":13,"title":["The clinical utility of gene testing for Alzheimer\u2019s disease"],"prefix":"10.3390","volume":"3","author":[{"given":"Emily R.","family":"Atkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Panegyres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,4,6]]},"container-title":["Neurology International"],"original-title":[],"link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ni\/article\/viewFile\/2140\/pdf_96","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ni\/article\/viewFile\/2140\/2816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T11:52:20Z","timestamp":1603799540000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ni\/article\/view\/ni.2011.e1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,6]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,3,6]]}},"URL":"https:\/\/doi.org\/10.4081\/ni.2011.e1","relation":{},"ISSN":["2035-8377","2035-8385"],"issn-type":[{"value":"2035-8377","type":"electronic"},{"value":"2035-8385","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4,6]]}}}