{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:08:58Z","timestamp":1696381738242},"reference-count":0,"publisher":"MDPI AG","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurol Int"],"abstract":"<jats:p>Parkinson\u2019s disease affects over one million people in the United States. Although there have been remarkable advances in uncovering the pathogenesis of this disabling disorder, the etiology is speculative. Medical treatment and operative procedures provide symptomatic relief only. Compression of the cerebral peduncle of the midbrain by the posterior cerebral artery in a patient with Parkinson\u2019s Disease (Parkinson\u2019s Disease) was noted on magnetic resonance imaging (MRI) scan and at operation in a patient with trigeminal neuralgia. Following the vascular decompression of the trigeminal nerve, the midbrain was decompressed by mobilizing and repositioning the posterior cerebral artery The patient's Parkinson's signs disappeared over a 48-hour period. They returned 18 months later with contralateral peduncle compression. A blinded evaluation of MRI scans of Parkinson's patients and controls was performed. MRI scans in 20 Parkinson's patients and 20 age and sex matched controls were evaluated in blinded fashion looking for the presence and degree of arterial compression of the cerebral peduncle. The MRI study showed that 73.7 percent of Parkinson's Disease patients had visible arterial compression of the cerebral peduncle. This was seen in only 10 percent of control patients (two patients, one of whom subsequently developed Parkinson\u2019s Disease); thus 5 percent. Vascular compression of the cerebral peduncle by the posterior cerebral artery may be associated with Parkinson\u2019s Disease in some patients. Microva\u00adscular decompression of that artery away from the peduncle may be considered for treatment of Parkinson\u2019s Disease in some patients.<\/jats:p>","DOI":"10.4081\/ni.2011.e7","type":"journal-article","created":{"date-parts":[[2011,12,21]],"date-time":"2011-12-21T15:00:28Z","timestamp":1324479628000},"page":"7","source":"Crossref","is-referenced-by-count":8,"title":["Parkinson\u2019s disease: an inquiry into the etiology and treatment"],"prefix":"10.3390","volume":"3","author":[{"given":"Peter J","family":"Jannetta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Whiting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn H","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph K","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Brillman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,8,30]]},"container-title":["Neurology International"],"original-title":[],"link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ni\/article\/viewFile\/2567\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ni\/article\/viewFile\/2567\/5329","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T11:52:15Z","timestamp":1603799535000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/ni\/article\/view\/ni.2011.e7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,7,5]]}},"URL":"https:\/\/doi.org\/10.4081\/ni.2011.e7","relation":{},"ISSN":["2035-8377","2035-8385"],"issn-type":[{"value":"2035-8377","type":"electronic"},{"value":"2035-8385","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8,30]]}}}