{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:39:48Z","timestamp":1773837588686,"version":"3.50.1"},"reference-count":0,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Rev"],"abstract":"<jats:p>Several factors such as chromosomal translocations, gene mutations, and polymorphisms are involved in the pathogenesis of leukemia\/lymphoma. Recently, the role of vitamin D (VD) and vitamin D receptor (VDR) polymorphisms in hematologic malignancies has been considered. In this review, we examine the possible role of VD levels, as well as VDR polymorphisms as prognostic biomarkers in leukemia\/lymphoma. Relevant English language literature were searched and retrieved from Google Scholar search engine (1985-2017). The following keywords were used: vitamin D, vitamin D receptor, leukemia, lymphoma, and polymorphism. Increased serum levels of VD in patients with leukemia are associated with a better prognosis. However, low VD levels are associated with a poor prognosis, and VDR polymorphisms in various leukemias can have prognostic value. VD biomarker can be regarded as a potential prognostic factor for a number of leukemias, including acute myeloblastic leukemia (AML), chronic lymphoblastic leukemia (CLL), and diffuse large B-cell lymphoma (DLBCL). There is a significant relationship between different polymorphisms of VDR (including Taq I and Fok I) with several leukemia types such as ALL and AML, which may have prognostic value.<\/jats:p>","DOI":"10.4081\/oncol.2018.366","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T21:03:23Z","timestamp":1539032603000},"source":"Crossref","is-referenced-by-count":3,"title":["Vitamin D and its receptor polymorphisms: New possible prognostic biomarkers in leukemias"],"prefix":"10.3389","author":[{"given":"Seyed Mohammad Sadegh","family":"Pezeshki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Amin","family":"Asnafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Khosravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Shahjahani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Azizidoost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Shahrabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2018,10,8]]},"container-title":["Oncology Reviews"],"original-title":[],"link":[{"URL":"https:\/\/www.oncologyreviews.org\/site\/article\/download\/366\/355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.oncologyreviews.org\/site\/article\/download\/366\/358","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.oncologyreviews.org\/site\/article\/download\/366\/355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T11:26:05Z","timestamp":1663241165000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.4081\/oncol.2018.366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4081\/oncol.2018.366","relation":{},"ISSN":["1970-5565","1970-5557"],"issn-type":[{"value":"1970-5565","type":"electronic"},{"value":"1970-5557","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10,8]]}}}