{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:20:59Z","timestamp":1777893659032,"version":"3.51.4"},"reference-count":0,"publisher":"Open Medical Publishing","issue":"1","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orthop Rev (Pavia)"],"abstract":"<jats:p>Knee osteoarthritis (KOA) is a very common condition with multifactorial etiology leading to severe pain and disability in the adult population. Although KOA is considered a non-inflammatory arthritis, upregulation of inflammatory and catabolic pathways with increased production of proinflammatory cytokines leading to cartilage degradation and extracellular matrix degeneration has been reported. Intra-articular injection of fresh fat derived stromal vascular fraction (SVF) fraction has been proposed as a valid and alternative treatment for symptomatic KOA that guarantees mechanical support through viscosupplementation, anti-inflammatory, and anabolic action. We retrospectively reviewed a case series of 84 consecutive adult patients with KOA who underwent intra-articular injection of fresh fat derived SVF. Significant improvement in pain levels (NRS score decrease 3.5\u00b11.1, p&lt;0.001), WOMAC pain (-7.02\u00b13.45 score change, p&lt;0.001), WOMAC stiffness (-1.97\u00b11.02, p&lt;0.001), and ROM improvement (+17.13\u00b15.22\u00b0, p&lt;0.001). The only complication noted was knee joint swelling lasting for less than 7 days after the injection in 7% of the patients.<\/jats:p>","DOI":"10.4081\/or.2021.9161","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T13:22:35Z","timestamp":1618838555000},"source":"Crossref","is-referenced-by-count":14,"title":["Fresh autologous stromal tissue fraction for the treatment of knee osteoarthritis related pain and disability"],"prefix":"10.52965","volume":"13","author":[{"given":"Stefano","family":"Santoprete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazie","family":"Bedini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Aurelio","family":"Nasto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Cipolloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Pola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"30777","published-online":{"date-parts":[[2021,3,31]]},"container-title":["Orthopedic Reviews"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/or\/article\/download\/9161\/8583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/orthopedicreviews.openmedicalpublishing.org\/article\/23418-fresh-autologous-stromal-tissue-fraction-for-the-treatment-of-knee-osteoarthritis-related-pain-and-disability.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T15:42:11Z","timestamp":1669995731000},"score":1,"resource":{"primary":{"URL":"https:\/\/orthopedicreviews.openmedicalpublishing.org\/article\/23418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,30]]}},"URL":"https:\/\/doi.org\/10.4081\/or.2021.9161","relation":{},"ISSN":["2035-8164","2035-8237"],"issn-type":[{"value":"2035-8164","type":"electronic"},{"value":"2035-8237","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,31]]}}}