{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:04:24Z","timestamp":1763705064627},"reference-count":0,"publisher":"PAGEPress Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Med Chir"],"abstract":"<jats:p>TEL-AML1 (ETV6-RUNX1) fusion gene which is formed prenatally in 1% of the newborns, is a common genetic abnormality in childhood Bcell precursor acute lymphoblastic leukemia. But only one child out of a hundred children born with this fusion gene develops leukemia (bottleneck phenomenon) later in its life, if contracts the second mutation. In other words, out of a hundred children born with TEL-AML1 only one child is at risk for leukemia development, which means that TEL-AML1 fusion gene is not sufficient for overt leukemia. There is a stringent requirement for a second genetic abnormality for leukemia development and this is the real or the ultimate cause of the leukemia &lt;em&gt;bottleneck&lt;\/em&gt; phenomenon. In most cases of TEL-AML1&lt;sup&gt;+&lt;\/sup&gt; leukemia, the translocation t(12;21) is complemented with the loss of the normal TEL gene, not involved in the translocation, on the contralateral 12p. The loss of the normal TEL gene, &lt;em&gt;i.e.&lt;\/em&gt; loss of heterozygosity at 12p, occurs postnatally during the mitotic proliferation of TEL-AML1&lt;sup&gt;+&lt;\/sup&gt; cell in the mitotic crossing over process. Mitotic crossing over is a very rare event with a frequency rate of 10&lt;sup&gt;\u20136&lt;\/sup&gt; in a 10 kb region. The exploration and identification of the environmental exposure(s) that cause(s) proliferation of the TELAML1&lt;sup&gt;+&lt;\/sup&gt; cell in which approximately 10&lt;sup&gt;6&lt;\/sup&gt; mitoses are generated to cause 12p loss of heterozygosity, &lt;em&gt;i.e.&lt;\/em&gt; TEL gene deletion, may contribute to the introduction of preventive measures for leukemia.<\/jats:p>","DOI":"10.4081\/pmc.2015.112","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T12:45:52Z","timestamp":1435668352000},"source":"Crossref","is-referenced-by-count":1,"title":["Mitotic crossover promotes leukemogenesis in children born with TEL-AML1 via the generation of loss of heterozygosity at 12p"],"prefix":"10.4081","volume":"37","author":[{"given":"Ivan","family":"Ivanovski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Garavelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivera","family":"Djuri\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"\u0106irovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"\u0160kori\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petar I.","family":"Ivanovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2015,11,24]]},"container-title":["La Pediatria Medica e Chirurgica"],"original-title":[],"link":[{"URL":"http:\/\/www.pediatrmedchir.org\/index.php\/pmc\/article\/viewFile\/112\/105","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T13:35:04Z","timestamp":1463578504000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pediatrmedchir.org\/index.php\/pmc\/article\/view\/pmc.2015.112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6,15]]}},"URL":"https:\/\/doi.org\/10.4081\/pmc.2015.112","relation":{},"ISSN":["2420-7748","0391-5387"],"issn-type":[{"value":"2420-7748","type":"electronic"},{"value":"0391-5387","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11,24]]}}}