{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:09:32Z","timestamp":1765354172034},"reference-count":19,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T00:00:00Z","timestamp":1248739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Idiopathic thrombocytopenic purpura (ITP) is an acute self-limited bleeding disorder that can progress to chronic form in 10-15% of the cases. Helicobacter pylori (H. pylori) infection is a possible cause of chronic ITP. We studied 30 children with resistant chronic ITP for H. pylori infection based on the detection of H. pylori fecal antigen. This retrospective study was based on data obtained from medical records of 30 children aged between five and 17 years (median age at ITP diagnosis was ten years). A specially-designed data sheet was used to record information on age, sex, duration of disease, family history of bleeding disorders, previous treatments and median platelet count. In patients with H. pylori infection, antimicrobial treatment consisted of amoxicillin, metronidazol and omeprazol. Response was assessed every month for one year and defined as complete (platelet count &gt;150x109\/L) or partial (platelet count between 50 and 150x109\/L). We detected H. pylori infection in 5 patients. In 4 of them increased platelet count was seen during one year of follow-up and in one patient the platelet count was acceptable during six months. Although the pathological mechanism of H. pylori-induced thrombocytopenia was unclear in our patient sample, the assessment of H. pylori infection and use of eradication therapy should be attempted in chronic and resistant ITP patients.<\/jats:p>","DOI":"10.4081\/pr.2009.e2","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T08:22:29Z","timestamp":1268986949000},"page":"e2","source":"Crossref","is-referenced-by-count":6,"title":["Does Helicobacter Pylori Play A Role in the Pathogenesis of Childhood Chronic Idiopathic Thrombocytopenic Purpura?"],"prefix":"10.3390","volume":"1","author":[{"given":"Maryam","family":"Maghbool","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masood","family":"Maghbool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Shahriari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2009,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1056\/NEJMra020542","article-title":"Helicobacter pylori infection","volume":"347","author":"Suerbaum","year":"2002","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(05)60004-9","article-title":"Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori","volume":"352","author":"Gasbarrini","year":"1998","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1651-2227.2003.tb02476.x","article-title":"Efficacy of H. pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura","volume":"92","author":"Jaing","year":"2003","journal-title":"Acta Paediatr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/08880019709028770","article-title":"Retrospective analysis of 78 children with chronic idiopathic thrombocytopenic purpura: follow - up from 1976 to 1996","volume":"14","author":"Yetgin","year":"1997","journal-title":"Paediatr Hematol Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1046\/j.1365-2141.2001.03194.x","article-title":"Absence of platelet response after eradication of Helicobacter pylori infection in patients with chronic idiopathic thrombocytopenic purpura","volume":"115","author":"Jarque","year":"2001","journal-title":"Br J Haematol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1046\/j.1365-2141.2002.03612.x","article-title":"Effect of H. pylori eradication on platelet Japanese recovery in patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura","volume":"118","author":"Kohda","year":"2002","journal-title":"Br J Haematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1523-5378.2007.00477.x","article-title":"Immune response to CagA protein is associated with improved platelet count after Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura,","volume":"12","author":"Kodama","year":"2007","journal-title":"Helicobacter"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood.V97.3.812","article-title":"Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura","volume":"97","author":"Emilia","year":"2001","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1182\/blood-2002-10-3201","article-title":"Helicobacter pylori and idiopathic thrombocytopenic purpura in children","volume":"101","author":"Rajantie","year":"2003","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1442-200x.2005.02058.x","article-title":"Helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura","volume":"47","author":"Hayashi","year":"2005","journal-title":"Pediatr Int"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/pbc.21991","article-title":"Absence of platelet recovery following Helicobacter pylori eradication in childhood chronic idiopathic thrombocytopenic purpura: a multi-center randomized controlled trial","volume":"53","author":"Treepongkaruna","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3324\/haematol.10940","article-title":"H. pylori infection in childhood chronic immune thrombocytopenic purpura","volume":"92","author":"Neefjes","year":"2007","journal-title":"Haematologica"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.amjmed.2004.09.014","article-title":"Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura","volume":"118","author":"Stasi","year":"2005","journal-title":"Am J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1532\/IJH97.04146","article-title":"Is eradication therapy useful as the first line of treatment in Helicobacter pylori-positive idiopathic thrombocytopenic purpura? Analysis of 207 eradicated chronic ITP cases in Japan","volume":"81","author":"Fujimura","year":"2005","journal-title":"Int J Hematol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0188-4409(00)00099-0","article-title":"A comprehensive review of the natural history of Helicobacter pylori infection in children","volume":"31","author":"Torres","year":"2000","journal-title":"Arch Med Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.diagmicrobio.2005.10.012","article-title":"Prevalence of Helicobacter pylori infection in children (south of Iran)","volume":"54","author":"Alborzi","year":"2006","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/00005176-199808000-00010","article-title":"Helicobacter pylori infection may undergo spontaneous eradication in children: a 2-year follow-up study","volume":"27","author":"Perri","year":"1998","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1086\/341415","article-title":"Prevalence of Helicobacter pylori in children: comparison between industrial and rural areas in Italy","volume":"35","author":"Dore","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1182\/asheducation-2008.1.206","article-title":"Helicobacter pylori and Chronic ITP","author":"Stasi","year":"2008","journal-title":"Hematology Am Soc Hematol Educ Program"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7503\/1\/1\/e2\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:06:14Z","timestamp":1644462374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/1\/1\/e2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,28]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,6]]}},"alternative-id":["pr.2009.e2"],"URL":"https:\/\/doi.org\/10.4081\/pr.2009.e2","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,28]]}}}