{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:11:55Z","timestamp":1781104315154,"version":"3.54.1"},"reference-count":13,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T00:00:00Z","timestamp":1269993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are employed in the evaluation of patients with suspected septic arthritis, osteomyelitis, and acute rheumatic fever. The purpose of this study is to determine if one test has greater sensitivity (rises earlier) than the other. Laboratory data were retrieved for pediatric patients hospitalized with one of the above three conditions, who had both ESR and CRP tests done on or shortly prior to admission. Sensitivity calculations were performed for mild, moderate, and severe degrees of ESR and CRP elevation. Microcytic erythrocytes, as defined by mean corpuscular volume (MCV) less than 80 \u03bcL, were identified to see if this affects the ESR. ESR or CRP sensitivities depend on the cutoff value (threshold) chosen as a positive test. The sensitivities were similar for similar degrees of elevation. ESR and CRP discordance was not significantly related to MCV. We concluded that the CRP does not rise earlier than the ESR (their sensitivities are similar). Previously published conclusions are dependent on arbitrary thresholds. We could not find any evidence that MCV affects the ESR.<\/jats:p>","DOI":"10.4081\/pr.2010.e10","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T13:48:07Z","timestamp":1276004887000},"page":"e10","source":"Crossref","is-referenced-by-count":10,"title":["Similar Erythrocyte Sedimentation Rate And C-Reactive Protein Sensitivities at the Onset of Septic Arthritis, Osteomyelitis, Acute Rheumatic Fever"],"prefix":"10.3390","volume":"2","author":[{"given":"Jonathan E.","family":"Reitzenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren G.","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareesh","family":"Mavoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/01241398-199009000-00015","article-title":"Acute Osteomyelitis in Children: A review of 116 cases","volume":"10","author":"Scott","year":"1990","journal-title":"J Pediatr Orthop"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/S0196-0644(05)80052-6","article-title":"Septic arthritis versus tansient synovitis of the hip: the value of screening laboratory tests","volume":"21","author":"Del Baccaro","year":"1992","journal-title":"Ann Emerg Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.93.1.59","article-title":"Serum C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in acute hematogenous osteomyelitis of Children","volume":"93","author":"Unkila-Kallio","year":"1994","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1136\/adc.71.1.59","article-title":"Management of irritable hip: a review of hospital admission policy","volume":"71","author":"Taylor","year":"1994","journal-title":"Arch Dis Child"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00003086-199705000-00022","article-title":"Sensitivity of objective parameters in the diagnosis of pediatric septic hips","volume":"338","author":"Klein","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/00365549850161124","article-title":"Acute osteomyelitis in children: a population-based retrospective study 1965 to 1994","volume":"30","author":"Dahl","year":"1998","journal-title":"Scand J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1445-2197.2003.02574.x","article-title":"Acute septic arthritis of the hip in children in northern australia","volume":"73","author":"Gandini","year":"2003","journal-title":"ANZ J Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/01241398-200305000-00017","article-title":"Significance of laboratory and radiologic findings for differentiating between septic arthritis and transient synovitis of the hip","volume":"23","author":"Jung","year":"2003","journal-title":"J Pediatr Orthop"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01241398-200305000-00018","article-title":"Assessment of the test characteristics of C-reactive protein for septic arthritis in children","volume":"23","author":"Levine","year":"2003","journal-title":"J Pediatr Orthop"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/00006454-200107000-00011","article-title":"Erythrocyte sedimentation rate and Creactive protein discrepancy and high prevalence of coronary artery abnormalities in Kawasaki disease","volume":"20","author":"Anderson","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1542\/pir.30.2.72","article-title":"Focus on Diagnosis: the erythrocyte sedimentation rate and the Creactive protein test","volume":"30","author":"Batlivala","year":"2009","journal-title":"Pediatr Rev"},{"key":"ref12","first-page":"501","article-title":"C-reactive protein (CRP) as an indicator of sepsis in orthopaedic trauma","volume":"56","author":"Gupta","year":"2002","journal-title":"Indian J Med Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00005176-200405000-00009","article-title":"Discordant erythrocyte sedimentation rate and C-reactive protein in children with inflammatory bowel disease taking azathioprine or 6-mercaptopurine","volume":"38","author":"Barnes","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Pediatric 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