{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T08:18:27Z","timestamp":1674893907215},"reference-count":12,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Neurobrucellosis manifesting as optic neuritis is a rare disease in childhood. We report a case of neurobrucellosis in a 11 year old girl leading to visual impairment and headache. Physical examination revealed mild oedema of right tibiotarsic joint and optic neuritis. Investigations showed CSF pleocytosis and a Brucella serum agglutination titer of 1\/640. Complete reversal of the symptoms was observed after appropriate antibiotic treatment. To our knowledge only four cases of neurobrucellosis manifesting with visual impairment in childhood are previously reported in literature.<\/jats:p>","DOI":"10.4081\/pr.2011.e11","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T12:23:42Z","timestamp":1303907022000},"page":"e11","source":"Crossref","is-referenced-by-count":5,"title":["Unilateral Optic Neuritis as a Presentation of Neurobrucellosis"],"prefix":"10.3390","volume":"3","author":[{"given":"Rita","family":"Marques","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Paulo","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Calhau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0163-4453(98)94279-7","article-title":"Central nervous system brucellosis: presentation, diagnosis and treatment","volume":"36","author":"Akdeniz","year":"1998","journal-title":"J Infect"},{"key":"ref2","first-page":"395","article-title":"Neurobrucellosis: Clinical and Neuro-imaging Correlation","volume":"25","author":"Al-Sous","year":"2004","journal-title":"AJNR"},{"key":"ref3","first-page":"254","article-title":"Optic neuritis in children","volume":"37","author":"Morales","year":"2000","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/clind\/15.4.582","article-title":"Neurobrucellosis: clinical and therapeutic features","volume":"15","author":"McLean","year":"1992","journal-title":"Clin Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.pediatrneurol.2008.12.011","article-title":"Neurobrucellosis: A Partially Treatable Cause of Vision Loss","volume":"40","author":"Tonekaboni","year":"2008","journal-title":"Pediatric Neurology"},{"key":"ref6","first-page":"762","article-title":"Neurobrucellosis in childhood: six new cases and a review of the literature","volume":"39","author":"Omar","year":"1997","journal-title":"DMCN"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1128\/jcm.30.1.222-224.1992","article-title":"Rapid diagnosis of Brucella melitensis in blood: some operational characterizations of the BACT\/ALERT","volume":"30","author":"Solomon","year":"1992","journal-title":"J Clin Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/clinids\/9.4.810","article-title":"Brucela meningitis","volume":"9","author":"Bouza","year":"1987","journal-title":"Rev Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1056\/NEJMra050570","article-title":"Brucellosis","volume":"352","author":"Pappas","year":"2005","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF02278157","article-title":"MRI of Brucella polyneuritis in a child","volume":"38","author":"Tali","year":"1996","journal-title":"Neuroradiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1651-2227.2005.tb03085.x","article-title":"Unusual presentation of brucellosis in a child: Acute blindness","volume":"94","author":"Karapinar","year":"2005","journal-title":"Acta Paediatrica"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/archinte.1991.00400040116026","article-title":"Brucella optic neuritis","volume":"151","author":"Elrazak","year":"1991","journal-title":"Arch Intern Med"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2036-7503\/3\/2\/e11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:15:00Z","timestamp":1644462900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/3\/2\/e11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,4]]}},"alternative-id":["pr.2011.e11"],"URL":"https:\/\/doi.org\/10.4081\/pr.2011.e11","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}