{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:07Z","timestamp":1790812807352,"version":"4.1.0"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Prune-Belly syndrome is a disorder characterized by the following triad of symptoms: deficiency of the abdominal muscles, malformations of the urinary tract and bilateral cryptorchidism. This study included a total of 16 patients. The findings included clinical characteristics, diagnostics, therapy and long-term clinical outcomes. All patients were asked to complete a questionnaire and, in some cases, were given further examination.  All patients were diagnosed with congenital aplasia of the abdominal wall and a variety of urogenital malformations. Cryptorchidism was present in 11 patients (68.8%), malformations of the prostate in 3 (18.8%), urethral malformations in 8 (50%) and mega-ureter in 14 patients (87.5%). A mega-bladder was observed in 13 patients (81.3%). Distinctive renal malformations, such as renal dysplasia, in 3 patients (18.8%) and hydronephrosis in 9 patients (56.3%), respectively. Abdominoplasty was performed on 4 patients (25%). Urethral surgery was performed in 10 patients (62.5%). Seven patients (43.8%) required ureter surgery, most of which involved re-implantation of the ureter and, in some cases, additional ureter modeling. Renal surgery was performed on 5 patients. Four patients with non-functioning kidneys with hydronephrosis underwent a nephrectomy and one patient pyeloplasty. We demonstrate that successful treatment is possible even in cases of serious and complex malformations, such as those of the Prune-Belly syndrome. Treatment must be tailored to the individual patient. The severity of the renal dysplasia is the main prognostic factor.<\/jats:p>","DOI":"10.4081\/pr.2012.e20","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T19:53:46Z","timestamp":1338839626000},"page":"e20","source":"Crossref","is-referenced-by-count":58,"title":["The Prune Belly Syndrome: Urological Aspects and Long-Term Outcomes of a Rare Disease"],"prefix":"10.3390","volume":"4","author":[{"given":"Vahudin","family":"Zugor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter E.","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos P.","family":"Labanaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,6,4]]},"reference":[{"key":"ref1","series-title":"Kinderurologie in Klinik und Praxis","first-page":"348","article-title":"Prune-Belly-Syndrom","author":"Duckett","year":"1986"},{"key":"ref2","first-page":"845","article-title":"VACTERL association with Prune-Belly syndrome","volume":"41","author":"Shah","year":"2004","journal-title":"Indian Pediatr"},{"key":"ref3","first-page":"322","article-title":"The prune-belly syndrome","volume":"21","author":"Schott","year":"1982","journal-title":"Urologe A"},{"key":"ref4","first-page":"207","article-title":"Current views of prune belly syndrome","volume":"27","author":"Van Ahlen","year":"1988","journal-title":"Urologe A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0022-5347(17)60675-X","article-title":"Prune belly syndrome","volume":"108","author":"Harley","year":"1972","journal-title":"J Urol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0022-5347(17)41793-9","article-title":"The prune belly syndrome: a review of its etiology, defects, treatment and prognosis","volume":"140","author":"Greskovich","year":"1988","journal-title":"J Urol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/01.ANC.0000278211.95767.05","article-title":"Prune belly syndrome. A focused physical assessment","volume":"7","author":"Woods","year":"2007","journal-title":"Adv Neonatal Care"},{"key":"ref8","first-page":"312","article-title":"Congenital mega-ureter","volume":"21","author":"Sigel","year":"1982","journal-title":"Urologe A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/adc.68.4.505","article-title":"Respiratory function in the prune-belly syndrome","volume":"68","author":"Crompton","year":"1993","journal-title":"Arch Dis Child"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jama.265.9.1179","article-title":"Dysplasia of the anterior abdominal musculature with multiple congenital anomalies. 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