{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:50:09Z","timestamp":1767847809177,"version":"3.49.0"},"reference-count":20,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>In preterm infants with very low birth weight (VLBW) &lt;1500 g the most important acquired intestinal diseases are necrotising enterocolitis (NEC) and focal intestinal perforation (FIP). We analyzed data of the neonatology module of national external comparative quality assurance for inpatients in the state of Baden-Wu\u0308rttemberg, Germany. Between 2010 and 2012, 59 of 3549 VLBW infants developed FIP (1.7%), 128 of them NEC (3.6%). In approximately 3% of infants with BW&lt;1000 g FIP was diagnosed, which was nearly 9 times more often than in infants with BW between 1250 and 1499 g (FIP frequency 0.36%). NEC frequency increased with decreasing BW and was more than 10 times higher in the smallest infants (BW&lt;750 g: 7.87%) compared to those with BW between 1250 and 1499 g (0.72%). The BW limit of 1250 g differentiates between groups of patients with distinguished risks for NEC and FIP.<\/jats:p>","DOI":"10.4081\/pr.2014.5194","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:35:04Z","timestamp":1392636904000},"page":"5194","source":"Crossref","is-referenced-by-count":7,"title":["Necrotizing Enterocolitis and Focal Intestinal Perforation in Neonatal Intensive Care Units in the State of Baden-Wu\u0308rttemberg, Germany"],"prefix":"10.3390","volume":"6","author":[{"given":"Thomas","family":"Bo\u0308hler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Bruder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ruef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Arand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Teufel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Mohrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Hentschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"ref1","article-title":"Beschluss \u00fcber eine \u00c4nderung der Vereinbarung \u00fcber Ma\u00dfnahmen zur Qualit\u00e4tssicherung der Versorgung von Fr\u00fch- und Neugeborenen vom 20","year":"2013","journal-title":"Juni"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/sj.jp.7211782","article-title":"Emerging trends in acquired neonatal intestinal disease: is it time to abandon Bell\u2019s criteria?","volume":"27","author":"Gordon","year":"2007","journal-title":"J Perinatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.sempedsurg.2005.05.003","article-title":"Ischemia and necrotizing enterocolitis: where, when, and how","volume":"14","author":"Nowicki","year":"2005","journal-title":"Semin Pediatr Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1072-7515(02)01344-3","article-title":"Spontaneous localized intestinal perforation in very-low-birth-weight infants: a distinct clinical entity different from necrotizing enterocolitis","volume":"195","author":"Pumberger","year":"2002","journal-title":"J Am Coll Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s00383-002-0839-7","article-title":"A comparison of the clinical presentation and outcome of focal intestinal perforation and necrotizing enterocolitis in very-low-birth-weight neonates","volume":"18","author":"Okuyama","year":"2002","journal-title":"Pediatr Surg Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/jp.2010.59","article-title":"Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis","volume":"30","author":"Sharma","year":"2010","journal-title":"J Perinatol"},{"issue":"Suppl 1","key":"ref7","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/jp.2008.44","article-title":"Evidence vs experience in the surgical management of necrotizing enterocolitis and focal 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(Daten\u00fcbermittlungsvereinbarung \u00a7 301)"},{"issue":"Suppl 1","key":"ref13","first-page":"76","article-title":"Fokal intestinale Perforation vs. nekrotisierende Enterokolitis bei Fr\u00fchgeborenen mit einem Geburtsgewicht <1500 g: zwei Entit\u00e4ten oder unterschiedliche Auspr\u00e4gungen eines Krankheitsbildes?","volume":"161","author":"Linge","year":"2013","journal-title":"Monatsschr Kinderheilkd"},{"key":"ref14","article-title":"Kinderan\u00e4sthesie. 3. Aufl.","author":"Frei","year":"2004"},{"key":"ref15"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000335325","article-title":"Surgical management of extremely low birth weight infants with neonatal bowel perforation: a single-center experience and a review of the literature","volume":"101","author":"Eicher","year":"2012","journal-title":"Neonatology"},{"key":"ref17","article-title":"Tracking medicine: a researcher\u2019s quest to understand health care","author":"Wennberg","year":"2004"},{"key":"ref18","first-page":"CD001241","article-title":"Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants","volume":"3","author":"Morgan","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref19","first-page":"CD005496","article-title":"Probiotics for prevention of necrotizing enterocolitis in preterm infants","author":"Alfaleh","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/jama.292.7.847","article-title":"Surgical mortality as an indicator of hospital quality: the problem with small sample size","volume":"292","author":"Dimick","year":"2004","journal-title":"JAMA"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5194\/4228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5194\/4231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5194\/5572","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7503\/6\/1\/5194\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:41:56Z","timestamp":1644464516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/6\/1\/5194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,17]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,2]]}},"alternative-id":["pr.2014.5194"],"URL":"https:\/\/doi.org\/10.4081\/pr.2014.5194","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,17]]}}}