{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:17:33Z","timestamp":1763057853599},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Hypoxic-ischemic encephalopathy (HIE) is an important cause of acute neurological damage in newborns at (or near) term. Several trials in recent years have shown that moderate hypothermia by total body cooling or selective head is an effective intervention to reduce mortality and major disability in infants survived a perinatal hypoxic-ischemic attack. Follow-up in these patients is very important to establish neurodevelopmental outcome, and specific markers can lead us to detect predicting sign for good or poor outcome. We reported a few cases of newborn with HIE treated with hypothermia, in whom the comparison between electroencephalogram (EEG) and magnetic resonance imaging (MRI) represents the first marker for neurodevelopment outcome prediction. The continuous EEG monitoring showed a depressed EEG activity with diffuse burst depression in 7 patients. No epileptic abnormalities were registered. In 10 out of 20 patients no abnormalities of the background activity and no epileptic abnormalities were observed. We found that a depressed EEG activity during the first 72 h of life and a diffused alteration of basal ganglia at MRI were correlated with a poor neurodevelopmental outcome at 18 months of follow-up.<\/jats:p>","DOI":"10.4081\/pr.2014.5532","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T14:31:43Z","timestamp":1415284303000},"page":"5532","source":"Crossref","is-referenced-by-count":8,"title":["Electroencephalogram and Magnetic Resonance Imaging Comparison as a Predicting Factor for Neurodevelopmental Outcome in Hypoxic Ischemic Encephalopathy Infant Treated with Hypothermia"],"prefix":"10.3390","volume":"6","author":[{"given":"Francesca","family":"Del Balzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Maiolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Papoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Properzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Spalice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2431-8-17","article-title":"The Toby study. 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Is the Apgar score predictive?","volume":"33","author":"Mercuri","year":"2002","journal-title":"Neuropediatrics"},{"key":"ref17","article-title":"EEG findings in cooled asphyxiated newborns and correlation with site and severity of brain damage.","author":"Briatore","year":"2012","journal-title":"Brain Dev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1055\/s-2007-986686","article-title":"Relationship between electroencephalography and magnetic resonance imaging after hypoxic-ischemic encephalopathy at term","volume":"24","author":"El-Ayuoty","year":"2007","journal-title":"Am J Perinatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0b013e31820af91a","article-title":"Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"76","author":"Nash","year":"2011","journal-title":"Neurology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0387-7604(89)80079-8","article-title":"The EEG evolution and neurological prognosis of neonates with perinatal hypoxia","volume":"11","author":"Takeuchi","year":"1989","journal-title":"Brain Dev"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5532\/4477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7503\/6\/3\/5532\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:43:53Z","timestamp":1644464633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/6\/3\/5532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,8]]}},"alternative-id":["pr.2014.5532"],"URL":"https:\/\/doi.org\/10.4081\/pr.2014.5532","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,1]]}}}