{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:10:56Z","timestamp":1762506656499},"reference-count":7,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Hashimoto\u2019s thyroiditis (HT) usually presents as painless thyroid swelling. Painful pediatric HT is a rare condition with limited literature on pain management. We report a 15- year-old female who presented with 4 weeks history of fatigue, malaise and progressive, painful midline thyroid swelling. There was no difficulty in swallowing, no fever or recent upper respiratory infection symptoms. Exam was remarkable for diffusely enlarged, very tender, and non-nodular thyroid. Thyroid function tests, C-reactive protein, and complete blood count were normal. Ultrasound revealed diffusely enlarged non-nodular, non-cystic gland with mild increased vascularity. Diagnosis of HT was confirmed by biopsy and thyroid antibodies. Over a 6 week period, pain management with ibuprofen, levothyroxine, corticosteroid, gabapentin and amitriptyline was unsuccessful. Ultimately, total thyroidectomy resulted in complete resolution of thyroid pain. We can conclude that thyroidectomy may be considered for the rare case of painful HT in children.<\/jats:p>","DOI":"10.4081\/pr.2015.5914","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T10:13:09Z","timestamp":1443435189000},"page":"5914","source":"Crossref","is-referenced-by-count":3,"title":["A Rare Case of Painful Goiter Secondary to Pediatric Hashimoto\u2019s Thyroiditis Requiring Thyroidectomy for Pain Control"],"prefix":"10.3390","volume":"7","author":[{"given":"Liladhar","family":"Kashyap","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhameed","family":"Alsaheel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Walvekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1210\/jc.2002-021498","article-title":"Painful Hashimoto\u2019s thyroiditis as an indication for thyroidectomy: clinical characteristics and outcome in seven patients","volume":"88","author":"Kon","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.7326\/0003-4819-104-3-355","article-title":"Hashimoto\u2019s thyroiditis. An uncommon cause of painful thyroid unresponsive to corticosteroid therapy","volume":"104","author":"Zimmerman","year":"1986","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1089\/thy.2012.0459","article-title":"Initial treatment with 15 mg of prednisolone daily is sufficient for most patients with subacute thyroiditis in Japan","volume":"23","author":"Kubota","year":"2013","journal-title":"Thyroid"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1001\/archinte.1983.00350100132024","article-title":"Current concepts of thyroiditis","volume":"143","author":"Levine","year":"1983","journal-title":"Arch Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1089\/thy.2005.15.340","article-title":"Successful treatment for recurrent painful Hashimoto\u2019s thyroiditis by total thyroidectomy","volume":"15","author":"Ohye","year":"2005","journal-title":"Thyroid"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2169\/internalmedicine.45.0144","article-title":"Painful Hashimoto\u2019s thyroiditis","volume":"45","author":"Kasagi","year":"2006","journal-title":"Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/BF03344075","article-title":"Autoimmune thyroid disease accompanied by recurring episodes of painful thyroid ameliorated by thyroidectomy","volume":"25","author":"Konno","year":"2002","journal-title":"J Endocrinol Invest"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5914\/4736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7503\/7\/3\/5914\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:49:16Z","timestamp":1644464956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/7\/3\/5914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9]]}},"alternative-id":["pr.2015.5914"],"URL":"https:\/\/doi.org\/10.4081\/pr.2015.5914","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}