{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T16:46:19Z","timestamp":1758991579087},"reference-count":10,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Mucormycosis is an uncommon but severe fungal infection, typically observed in immunocompromized patients. We report a case of acute lymphoblastic leukemia complicated by rhino-oculo-cerebral mucormycosis in a pediatric patient. Combination lipid polyeneechinocandin therapy, along with surgical debridement appeared to be effective. Nevertheless, a severe relapse occurred during posaconazole prophylaxis; antifungal therapy, hemimaxillectomy and suspension of chemotherapy were performed. Although mucormycosis is a frequently lethal infection, prompt diagnosis and aggressive treatment can be successful even in cases of relapse.<\/jats:p>","DOI":"10.4081\/pr.2015.5938","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T10:13:09Z","timestamp":1443435189000},"page":"5938","source":"Crossref","is-referenced-by-count":9,"title":["Recurrent Rhino-Ocular-Cerebral Mucormycosis in a Leukemic Child: A Case Report and Review of Pediatric Literature"],"prefix":"10.3390","volume":"7","author":[{"given":"Francesco","family":"De Leonardis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Perillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Giudice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Favia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2217\/fmb.13.78","article-title":"Epidemiology and treatment of mucormycosis","volume":"8","author":"Lewis","year":"2013","journal-title":"Future Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e785","DOI":"10.1111\/j.1439-0507.2011.02025.x","article-title":"Mucormycosis in paediatric patients: demographics, risk factors and outcome of 12 contemporary cases","volume":"54","author":"D\u00e4britz","year":"2011","journal-title":"Mycoses"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/myc.12010","article-title":"Focus on invasive mucormycosis in paediatric haematology oncology patients: a series of 11 cases","volume":"56","author":"Phulpin-Weibel","year":"2013","journal-title":"Mycoses"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/MPH.0b013e3181bdbca0","article-title":"Sinonasal mucormycosis in immuno-compromised pediatric patients","volume":"31","author":"Rassi","year":"2009","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref5","first-page":"163","volume":"30","author":"Popa","year":"2008","journal-title":"Rhinocerebral mucormycosis in a child with acute lymphoblastic leukemia: a case report"},{"key":"ref6","first-page":"515","article-title":"Oral mucormycosis in children with leukemia: report of 2 cases","volume":"38","author":"Dogan","year":"2007","journal-title":"Quintessence Int"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1525-1470.2007.00398.x","article-title":"Primary cutaneous zygomycosis in two immunocompromised children","volume":"24","author":"Cantatore-Francis","year":"2007","journal-title":"Pediatr Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4103\/0971-5851.125254","article-title":"Successful outcome of mucormycosis in two children on induction therapy for acute lymphoblastic leukemia","volume":"34","author":"Gupta","year":"2013","journal-title":"Indian J Med Paediatr Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00043426-200208000-00017","article-title":"Rhinocerebral mucormycosis in a boy with recurrent acute lymphoblastic leukemia: long-term survival with systemic antifungal treatment","volume":"24","author":"Wehl","year":"2002","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1086\/589857","article-title":"Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis","volume":"47","author":"Reed","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5938\/4739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7503\/7\/3\/5938\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:49:53Z","timestamp":1644464993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/7\/3\/5938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9]]}},"alternative-id":["pr.2015.5938"],"URL":"https:\/\/doi.org\/10.4081\/pr.2015.5938","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}