{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:15:46Z","timestamp":1774271746091,"version":"3.50.1"},"reference-count":12,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>We observed late-onset rashes in patients with group A beta-hemolytic streptococcal (GAS) pharyngitis. Of 1028 patients with GAS pharyngitis, which was principally treated with amoxicillin, we evaluated those who developed a late-onset rash and excluded those with scarlet fever alone. Twenty-one patients developed a rash (2.0%, 95% confidence interval, 1.3- 3.1%), 7 to 20 days (median, 8 days) after GAS pharyngitis onset. The rashes were characterized by maculopapules, which increased in size with coalescence and some developing into plaques, with a symmetrical distribution with a propensity for the extremities, including the palms and soles. The clinical courses of the patients were good, and the rashes subsided within 14 days. A non-immediate reaction to \u03b2-lactams, which usually manifests as a maculopapular rash, is a possible cause in our patients, however, repeated courses of amoxicillin in 3 patients did not induce the rash. The underlying mechanism of the late-onset rash after GAS pharyngitis with amoxicillin treatment remains unclear.<\/jats:p>","DOI":"10.4081\/pr.2015.5951","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T14:55:25Z","timestamp":1450450525000},"page":"5951","source":"Crossref","is-referenced-by-count":1,"title":["Late-Onset Rash in Patients with Group A Beta-hemolytic Streptococcal Pharyngitis Treated with Amoxicillin"],"prefix":"10.3390","volume":"7","author":[{"given":"Masahiko","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1056\/NEJMcp1009126","article-title":"Streptoccocal pharyngitis","volume":"364","author":"Wesells","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","series-title":"Nelson textbook of Pediatrics","first-page":"1135","article-title":"Group A streptococcus","author":"Gerber","year":"2007"},{"key":"ref3","first-page":"1883","article-title":"Erythema multiforme","volume":"74","author":"Lamoreux","year":"2006","journal-title":"Am Fam Physician"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1056\/NEJMcp1104080","article-title":"Exanthematous drug eruptions","volume":"366","author":"Stern","year":"2012","journal-title":"N Engl J Med"},{"key":"ref5","first-page":"498","article-title":"Prospective study of the exanthema after AMPC administration in streptococcal pharyngitis","volume":"13","author":"Kodo","year":"2011","journal-title":"Gairai Shounika"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1398-9995.2004.00678.x","article-title":"Diagnosis of nonimmediate reactions to blactam antibiotics","volume":"59","author":"Romano","year":"2004","journal-title":"Allergy"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/bmj.1.5844.7","article-title":"Prospective study of ampicillin rash","volume":"1","year":"1973","journal-title":"BMJ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1001\/jama.1972.03200080042010","article-title":"Reactions associated with ampicillin therapy","volume":"220","author":"Bierman","year":"1972","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/adc.76.6.513","article-title":"Aminopenicillin allergy","volume":"76","author":"Romano","year":"1997","journal-title":"Arch Dis Child"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1399-3038.2011.01169.x","article-title":"Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests","volume":"22","author":"Ponvert","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2340\/00015555-1254","article-title":"One-week oral challenge with penicillin in diagnosis of penicillin allergy","volume":"92","author":"Hjortlund","year":"2012","journal-title":"Acta Derm Venerol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1398-9995.2008.01674.x","article-title":"Detection and quantification of drug-specific T cells n penicillin allergy","volume":"64","author":"Rozieres","year":"2009","journal-title":"Allergy"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/viewFile\/5951\/5083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7503\/7\/4\/5951\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:50:40Z","timestamp":1644465040000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/7\/4\/5951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["pr.2015.5951"],"URL":"https:\/\/doi.org\/10.4081\/pr.2015.5951","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,18]]}}}