{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:23:15Z","timestamp":1789402995375,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Hemophilia A is a X-linked hereditary condition that lead to decreased factor VIII activity, occurs mainly in males. Decreased factor VIII activity leads to increased risk of bleeding events. During neonatal period, diagnosis is made after post-partum bleeding complication or unexpected bleeding after medical procedures. Subgaleal hemorrhage during neonatal period is a rare, severe extracranial bleeding with high mortality and usually related to traumatic labor or coagulation disorders. Subgaleal hemorrhage complications result from massive bleeding. We present a neonate with unremarkable family history and uneventful pregnancy with a vaginal delivery with no instrumentation, presenting with severe subgaleal bleeding at 52 hours of life. Aggressive support measures were implemented and bleeding managed. The unexpected bleeding lead to a coagulation study and the diagnosis of severe hemophilia A. There were no known sequelae. This case shows a rare hemophilia presentation reflecting the importance of coagulation studies when faced with unexplained severe bleeding.<\/jats:p>","DOI":"10.4081\/pr.2015.6338","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T07:10:07Z","timestamp":1450768207000},"page":"6338","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal Hemophilia: A Rare Presentation"],"prefix":"10.3390","volume":"7","author":[{"given":"Nuno","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Proen\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Godinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0950-3536(96)80059-X","article-title":"The molecular basis of haemophilia A and B","volume":"9","author":"Gianelli","year":"1996","journal-title":"Baillieres Clin Haematol"},{"key":"ref2","series-title":"Nathan and Oski\u2019s hematology of infancy and childhood","year":"2009"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1365-2141.2010.08545.x","article-title":"Guideline on the management of haemophilia in the fetus and neonate","volume":"154","author":"Chalmers","year":"2011","journal-title":"Br J Haematol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MBC.0b013e32835975d6","article-title":"Diagnosis and treatment of intracranial hemorrhage in children with haemophilia","volume":"24","author":"Nagel","year":"2012","journal-title":"Blood Coagul Fibrinol"},{"key":"ref5","first-page":"378","article-title":"Intracranial haemorrhage in haemophilia A and B","volume":"140","author":"Ljung","year":"2007","journal-title":"Br J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2516.2008.01722.x","article-title":"Haemophilia in the first years of life","volume":"14","author":"Ljung","year":"2008","journal-title":"Haemophilia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2516.2008.01722.x","article-title":"Haemophilia in the first years of life","volume":"14","author":"Ljung","year":"2008","journal-title":"Haemophilia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1651-2227.1990.tb11438.x","article-title":"Diagnostic symptons of severe and moderate haemophilia A and B. 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