{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:41:36Z","timestamp":1792690896902,"version":"4.5.0"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>A limited number of sclerosing Angiomatoid Nodular Transformation (SANT) have been reported in pediatric age. We describe the first case of SANT occurring in a nine-week-old female infant that was admitted to our unit for severe abdominal distension and rectal bleeding. Enlarged spleen was detected on physical examination. Laboratory investigations revealed severe anemia and coagulation abnormalities. Abdominal ultrasound and computed tomography revealed ascites and splenomegaly with a large mass at the lower medial splenic pole. A diagnosis of intraabdominal hemorrhage was presumed and an exploratory laparotomy was performed. A complete transformation of the giant splenomegaly to bossellated masses and multiple bleeding capsular ruptures without subcapsular hematoma were found and an urgent splenectomy was performed. At histology, a SANT was diagnosed (CD34, CD31, CD8 positivity). The postoperative follow up was uneventful. SANT may also occur in infancy with a potentially lifethreatening presentation. Splenectomy may represent the only treatment in severe cases.<\/jats:p>","DOI":"10.4081\/pr.2019.7848","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T07:52:51Z","timestamp":1558597971000},"page":"7848","source":"Crossref","is-referenced-by-count":18,"title":["Sclerosing Angiomatoid Nodular Transformation Presend Nodulartransformation Presenting with Abdominal Hemorrhage: First Report in Infancy"],"prefix":"10.3390","volume":"11","author":[{"given":"Gloria","family":"Pelizzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Lorenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orietta","family":"Doria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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transformation of the spleen: CT, MR, PET, and \u2079\u2079(m)Tc-sulfur colloid SPECT CT findings with gross and histopathological correlation","volume":"35","author":"Thacker","year":"2010","journal-title":"Abdom Imaging"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1148\/rg.244045006","article-title":"From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation","volume":"24","author":"Abbott","year":"2004","journal-title":"Radiographics"},{"key":"ref10","first-page":"7020538","article-title":"Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time","volume":"2018","author":"Cipolla","year":"2018","journal-title":"Case Rep Surg"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13000-015-0312-2","article-title":"Multifocal sclerosing angiomatoid nodular transformation of the spleen: a case report and review of literature","volume":"11","author":"Cao","year":"2015","journal-title":"Diagn Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5005\/jp-journals-10018-1221","article-title":"Sclerosing angiomatoid nodular transformation of the spleen: An uncommon cause of abdominal pain","volume":"7","author":"Atas","year":"2017","journal-title":"Euroasian J Hepatogastroenterol"},{"key":"ref13","first-page":"129","article-title":"Sclerosing angiomatoid nodular transformation (SANT) of spleen: a case report describing cytology, histology, immunoprofile and differential diagnosis","volume":"23","author":"\u00d6nder","year":"2012","journal-title":"Cytology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00428-007-0422-7","article-title":"CD30 and Epstein\u2013Barr virus RNA expression in sclerosing angiomatoid nodular transformation of spleen","volume":"451","author":"Weinreb","year":"2007","journal-title":"Virchows Arch"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00428-008-0648-z","article-title":"Detection of Epstein-Barr virusencoded small RNA-expressed myofibroblasts and IgG4-producing plasma cells in sclerosing angiomatoid nodular transformation of the spleen","volume":"53","author":"Kashiwagi","year":"2008","journal-title":"Virchows Arch"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s00595-013-0499-3","article-title":"Sclerosing angiomatoid nodular transformation of the spleen related to IgG4-associated disease: report of a case","volume":"43","author":"Kim","year":"2013","journal-title":"Surg Today"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1440-1827.2009.02456.x","article-title":"Sclerosing angiomatoid nodular transformation of the spleen (SANT): clinicopathological study of 10 cases with or without abdominal disseminated calcifying fibrous tumors, and the presence of a 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