{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:13:09Z","timestamp":1792858389750,"version":"4.5.0"},"reference-count":15,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Reports"],"abstract":"<jats:p>Streptococcus pneumoniae is a rare cause of neonatal sepsis, and it is associated with significant morbidity and a very high fatality rate. The infection is usually acquired intrapartum, from the colonization of the maternal genital tract. Most affected neonates have an early-onset presentation of symptoms, usually within the first 48 hours after birth, which is similar to other causes of neonatal sepsis such as Streptococcus Agalactiae or Escherichia Coli. However, the virulence seems to be higher for Streptococcus pneumoniae, which has in addition a higher infant invasion\/ maternal colonization ratio than Streptococcus Agalactiae. Pneumococcal vaccination has not resulted in a significant decline of neonatal cases. Many cases included ours, involved serotypes not present in the vaccine. Other strategies to protect these infants are necessary. We describe a late preterm infant with a fatal, early-onset sepsis caused by Streptococcus Pneumoniae serotype 28 A. Maternal vaginal culture grew the same bacteria.<\/jats:p>","DOI":"10.4081\/pr.2019.7953","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T08:39:13Z","timestamp":1553762353000},"page":"7953","source":"Crossref","is-referenced-by-count":4,"title":["Fulminant Early-Onset Neonatal Sepsis due to Streptococcus Pneumoniae: Case Report and Review of the Literature"],"prefix":"10.3390","volume":"11","author":[{"given":"Carlos","family":"Aldana-Valenzuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Marina","family":"Rodriguez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Guill\u00e9n-Blancas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"key":"ref1","first-page":"442","article-title":"Fatal early-onset neonatal sepsis due to Streptococcus pneumoniae","volume":"53","author":"Nallusamy","year":"1998","journal-title":"Med J Malaysia"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/adc.69.3_Spec_No.317","article-title":"Pneumococcal infection in the newborn","volume":"69","author":"Primhak","year":"1993","journal-title":"Arch Dis Child"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3109\/15513815.2015.1033073","article-title":"streptococcus pneumoniae: the forgotten microorganism in neonatal sepsis","volume":"34","author":"Fernandez","year":"2015","journal-title":"Fetal Pediatr Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1542\/peds.112.5.1095","article-title":"Streptococcus pneumoniae infections in the neonate","volume":"112","author":"Hoffman","year":"2003","journal-title":"Pediatrics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1055\/s-2004-835967","article-title":"Streptococcus pneumoniae: an old bug with significant maternal-newborn implications","volume":"21","author":"Sallam","year":"2004","journal-title":"Am J Perinatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/cid\/cis934","article-title":"Impact of the 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in infants younger than 90 days in England and Wales","volume":"56","author":"Ladhani","year":"2013","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/jpids\/pix034","article-title":"invasive pneumococcal disease in infants aged 0-60 days in the United States in the 13-valent pneumococcal conjugate era","volume":"17","author":"Olarte","year":"2018","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/cid\/cir444","article-title":"Pneumococcal conjugate vaccine given shortly after birth stimulates effective antibody concentrations and primes immunological memory for sustained infant protection","volume":"53","author":"Scott","year":"2011","journal-title":"Clin Infec Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00404-011-2020-9","article-title":"Intrapartum colonization with Streptococcus Pneumoniae, early-onset sepsis and deficient specific neonatal immune responses","volume":"285","author":"Faust","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1097\/INF.0000000000001818","article-title":"Early-onset neonatal pneumococcal sepsis: A fatal case report and brief literature review","volume":"37","author":"Jarovsky","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"ref11","first-page":"CD004903","article-title":"Pneumococcal vaccination during pregnancy for preventing infant infection","volume":"1","author":"Chaithongwongwatthana","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"E79","DOI":"10.1111\/j.1440-1754.2010.01929.x","article-title":"Streptococcus Pneumoniae sepsis in the newborn","volume":"48","author":"Malhotra","year":"2012","journal-title":"J Paediatr Child Health"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00006454-199911000-00016","article-title":"Neonatal Streptococcus Pneumoniae infection: Case reports and review of the literature","volume":"18","author":"Gomez","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/01.PCC.0000163677.58249.77","article-title":"Early-onset neonatal pneumococcal sepsis syndrome","volume":"6","author":"McAdams","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1097\/INF.0b013e31829ebeea","article-title":"Early-onset Streptococcus pneumoniae neonatal sepsis and meningitis in the 13-valent vaccine era","volume":"32","author":"Fothy","year":"2013","journal-title":"Pediatr Infect Dis J"}],"container-title":["Pediatric Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/download\/7953\/7788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/pr\/article\/download\/7953\/7884","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7503\/11\/1\/7953\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T04:06:51Z","timestamp":1644466011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7503\/11\/1\/7953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,27]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["pr.2019.7953"],"URL":"https:\/\/doi.org\/10.4081\/pr.2019.7953","relation":{},"ISSN":["2036-7503"],"issn-type":[{"value":"2036-7503","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,27]]}}}