{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:12:53Z","timestamp":1762459973505,"version":"3.40.5"},"reference-count":17,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatismo"],"abstract":"<jats:p>The prevalence of osteoporosis is about three times greater in people living with HIV than in the general population. Bisphosphonates are the only class of antiresorptive drugs which have proved to be safe and effective in HIV patients. However, bisphosphonates are not recommended in women of childbearing age due to an increased rate of associated neonatal complications. To the best of our knowledge no reports on the use of denosumab in HIV-infected individuals have been published so far. We describe a 38 year-old woman with HIV, osteoporosis and vertebral fractures treated with denosumab, a monoclonal antibody targeting RANKL. After four years of treatment, bone mineral density improved, no new fractures occurred, and neither HIV reactivation nor opportunistic infections were observed. We show that denosumab could be a safe and effective approach for osteoporosis in patients with HIV and could be considered in women of childbearing age.<\/jats:p>","DOI":"10.4081\/reumatismo.2021.1358","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T07:00:48Z","timestamp":1618902048000},"page":"54-58","source":"Crossref","is-referenced-by-count":9,"title":["Denosumab for the treatment of HIV-associated osteoporosis with fractures in a premenopausal woman"],"prefix":"10.4081","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-3357","authenticated-orcid":false,"given":"E.","family":"Marasco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mussa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-2734","authenticated-orcid":false,"given":"F.","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bobbio-Pallavicini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-0373","authenticated-orcid":false,"given":"R.","family":"Maserati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-3925","authenticated-orcid":false,"given":"C.","family":"Montecucco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bogliolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"202","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801022eb"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.1007\/s40506-017-0109-9"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161270"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10055"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-eular.7858"},{"key":"208","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000400"},{"key":"209","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1319"},{"key":"210","doi-asserted-by":"publisher","DOI":"10.1086\/656412"},{"key":"211","doi-asserted-by":"publisher","DOI":"10.2174\/1389450033347109"},{"key":"212","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0052"},{"key":"213","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1569"},{"key":"214","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3234-7"},{"key":"215","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.05.010"},{"key":"216","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3337"},{"key":"217","unstructured":"Pfeiler GS, Egle D, Greil R, et al. Fracture risk after stopping adjuvant denosumab in hormone receptor positive breast cancer patients on aromatase inhibitor therapy \u2013 an analysis of 3,425 postmenopausal patients in the phase III ABCSG-18 trial. ASBMR 2018 Annual Meeting, 2018: Oral Presentations, Presentation Number: LB-1167."},{"key":"218","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59143-8"}],"container-title":["Reumatismo"],"original-title":[],"link":[{"URL":"https:\/\/reumatismo.org\/index.php\/reuma\/article\/download\/1358\/906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reumatismo.org\/index.php\/reuma\/article\/download\/1358\/906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T13:22:42Z","timestamp":1637760162000},"score":1,"resource":{"primary":{"URL":"https:\/\/reumatismo.org\/index.php\/reuma\/article\/view\/1358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,4,20]]}},"URL":"https:\/\/doi.org\/10.4081\/reumatismo.2021.1358","relation":{},"ISSN":["2240-2683","0048-7449"],"issn-type":[{"type":"electronic","value":"2240-2683"},{"type":"print","value":"0048-7449"}],"subject":[],"published":{"date-parts":[[2021,4,19]]}}}