{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:08:10Z","timestamp":1747224490163,"version":"3.40.5"},"reference-count":10,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatismo"],"abstract":"<jats:p>The case of a patient suffering from systemic lupus erythematosus with associated antiphospholipid antibody syndrome is described. In this patient, on protein electrophoresis, two monoclonal immunoglobulin G \u03bb and k peaks were seen, defining a condition of biclonal gammopathy of undetermined significance (BGUS). This condition is extremely rare, especially in chronic inflammatory rheumatic diseases. The criteria of a BGUS are defined. We also underline how this condition can be the expression of a concomitant unrecognized cancer, a possible amyloidosis or an infectious process.<\/jats:p>","DOI":"10.4081\/reumatismo.2021.1431","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T16:43:27Z","timestamp":1644252207000},"source":"Crossref","is-referenced-by-count":0,"title":["Biclonal gammopathy of undetermined significance in a patient with systemic lupus erythematosus and antiphospholipid syndrome"],"prefix":"10.4081","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7342-6350","authenticated-orcid":false,"given":"V.","family":"Bruzzese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2055-7282","authenticated-orcid":false,"given":"P.","family":"Scolieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"1128","doi-asserted-by":"crossref","unstructured":"Gastelum-Cano JM, Fragoso-Flores J, Noffal-Nuno VM, et al. An unusual pattern in serum protein electrophoresis to take in mind: a case report. Prac Lab Med. 2021; 24: e00200.","DOI":"10.1016\/j.plabm.2020.e00200"},{"key":"1129","doi-asserted-by":"crossref","unstructured":"Mullikin TC, Rajkumar SV, Dispenzieri A, et al. Clinical characteristics and outcomes in biclonal gammopathies. Am J Hematol. 2016; 91: 473-5.","DOI":"10.1002\/ajh.24319"},{"key":"1130","doi-asserted-by":"crossref","unstructured":"Garcia-Garcia P, Enciso-Alvarez K, Diaz-Espada F, et al. Biclonal gammopathies: retrospective study of 47 patients. Rev Clin Esp. 2015; 215: 18-24.","DOI":"10.1016\/j.rceng.2014.07.004"},{"key":"1131","unstructured":"Lagan\u00e0 B, Podest\u00e0 E, Picchianti Diamanti A, et al. Schnitzler\u2019s syndrome with biclonal gammopathy successfully treated with hydroxychloroquine and low dose steroids. Clin Exp Rheumatol. 2008; 26: 1161."},{"key":"1132","doi-asserted-by":"crossref","unstructured":"Castro I, Arroyo C, Yanez V, et al. Multiple myeloma in systemic lupus erythematosus. Report of two cases. Rev Med Chil. 2018; 146: 670-4.","DOI":"10.4067\/s0034-98872018000500670"},{"key":"1133","doi-asserted-by":"crossref","unstructured":"Nagashima T, Muroi K, Kawano-Yamamoto C, et al. Paraproteinemia after hematopoietic stem cell transplantation. Leuk Lymphomas. 2004; 45: 135-7.","DOI":"10.1080\/1042819031000139729"},{"key":"1134","unstructured":"Bruzzese V. Monoclono nella cancro-cirrosi. Clin Ter. 1989; 131: 41-3."},{"key":"1135","doi-asserted-by":"crossref","unstructured":"Westerman R, Zobbe K, Cordtz R, et al. Increased cancer risk in patient with cutaneous lupus erythematosus and systemic lupus erythematosus compared with the general population: a Danish nationwide cohort study. Lupus. 2021 [Epub ahead of print].","DOI":"10.1177\/0961203321990106"},{"key":"1136","doi-asserted-by":"crossref","unstructured":"Chen C, Sun C. Multifocal head and neck amyloidosis as a diagnostic clue of systemic lupus erythematosus (SLE): a case report. Medicine (Baltimore). 2019; 98: e16830.","DOI":"10.1097\/MD.0000000000016830"},{"key":"1137","unstructured":"Chenng WI, Leung VKS, Luke ISL, et al. Splenic tuberculosis associated with monoclonal gammopathy of undetermined significance and pericarditis. Hong Kong Med J. 2009; 15: 291."}],"container-title":["Reumatismo"],"original-title":[],"link":[{"URL":"https:\/\/www.reumatismo.org\/index.php\/reuma\/article\/download\/1431\/925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.reumatismo.org\/index.php\/reuma\/article\/download\/1431\/925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T16:44:27Z","timestamp":1644252267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.reumatismo.org\/index.php\/reuma\/article\/view\/1431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,7]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12,31]]}},"URL":"https:\/\/doi.org\/10.4081\/reumatismo.2021.1431","relation":{},"ISSN":["2240-2683","0048-7449"],"issn-type":[{"type":"electronic","value":"2240-2683"},{"type":"print","value":"0048-7449"}],"subject":[],"published":{"date-parts":[[2022,2,7]]}}}