{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T04:30:09Z","timestamp":1689654609762},"reference-count":25,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatismo"],"abstract":"<jats:p>Arthur Conan Doyle, the creator of Sherlock Holmes, was an experienced physician who treated gouty patients. A gouty character appears in The Adventure of the Missing Three-Quarter, a Sherlock Holmes novel. This offers the possibility of discussing gout from the peculiar perspective of a medical writer in light of the historical-medical context of the time. This study was conducted using Conan Doyle\u2019s autobiographical, scientific, and literary primary sources, as well as past and current medical literature. The Adventure of the Missing Three-Quarter was autobiographical. Conan Doyle himself was a rugby player and his wife died of tuberculosis. Furthermore, in 1884, in The Lancet, he described the hereditary case of a female gouty patient, presenting with ocular manifestations. In agreement with the concept of rich man\u2019s gout, the gouty patient of Sherlock Holmes\u2019 story, Lord Mount James, was a rich irascible noble but he was not addicted to the pleasures of food and sex. Following the usual funny representation of gouty patients, Conan Doyle made fun of Lord Mount James, but he misquoted a true case of gout cited in the literature. In his scientific and literary production on gout, Conan Doyle stuck to the most updated medical concepts of the time, demonstrating an uncommon knowledge of scientific literature.<\/jats:p>","DOI":"10.4081\/reumatismo.2023.1570","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T09:38:06Z","timestamp":1689586686000},"source":"Crossref","is-referenced-by-count":0,"title":["Arthur Conan Doyle, Sherlock Holmes, and gout"],"prefix":"10.4081","volume":"75","author":[{"given":"E.","family":"Damiani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"4476","unstructured":"Conan Doyle A. The romance of medicine. St. Mary's Hospital Gazette 1910; 16: 100-6."},{"key":"4477","unstructured":"Conan Doyle A. The adventure of the missing three quarter. Strand Magazine 1904; 28: 123-5."},{"key":"4478","unstructured":"Lellenberg J, Stashower D, Foley C. Arthur Conan Doyle a life in letters. New York: The Penguin Press, 2007."},{"key":"4479","unstructured":"Conan Doyle A. Memories and adventures. London, UK: Hodder and Stoughton, 1924: 17-28."},{"key":"4480","doi-asserted-by":"crossref","unstructured":"Marshall F. The four three-quarter system. Chums 1893; 1: 398.","DOI":"10.1093\/nq\/s8-III.73.398a"},{"key":"4481","unstructured":"Budd A. Past development in rugby football and the future of the game. In: Marshall F, editor. Football: the rugby union game. London: Cassell and Company, 1892: 115-38."},{"key":"4482","doi-asserted-by":"crossref","unstructured":"Conan Doyle A. The remote effects of gout. Lancet 1884; 2: 978-9.","DOI":"10.1016\/S0140-6736(02)28955-2"},{"key":"4483","unstructured":"Fothergill JM. Gout in its protean aspects. Detroit: George S. Davies, 1883."},{"key":"4484","doi-asserted-by":"crossref","unstructured":"Boyle JA, Campbell S, Duncan AM, Greig WR, Buchanan WW. Serum uric acid levels in normal pregnancy with observations on the renal excretion of urate in pregnancy. J Clin Pathol 1966; 19: 501-3.","DOI":"10.1136\/jcp.19.5.501"},{"key":"4485","unstructured":"Fagge CH, Pye-Smith PH. The principles and practice of the medicine. London: J. and A. Churchill, 1891: 676."},{"key":"4486","doi-asserted-by":"crossref","unstructured":"Reginato AM, Mount DB, Yang I, Choi HK. The genetics of hyperuricaemia and gout. Nat Rev Rheumatol 2012; 8: 610-21.","DOI":"10.1038\/nrrheum.2012.144"},{"key":"4487","doi-asserted-by":"crossref","unstructured":"Barranco-Trabi J, Mank V, Minns R, Ryan R, Roberts J. Ocular manifestations in gout: an unusual presentation of gout. Clin Rheumatol 2022; 41: 1613-4.","DOI":"10.1007\/s10067-022-06084-4"},{"key":"4488","unstructured":"Asz-Sigall D, Arenas R, Dominguez-Cherit J, Vega-Memije ME. Gouty tophi: the great mimicker. Med Cuban Iber Lat Am 2005; 33: 76-9. [Article in Spanish]"},{"key":"4489","unstructured":"Von Str\u00fcmpell A. A text-book of medicine for students and practitioners. New York: Appleton and Company, 1887: 929."},{"key":"4490","unstructured":"Centenary banquet: held at the hotel cecil, monday, may 22nd, 1905. Med Chir Trans 1905; 88: cl-clxxvii."},{"key":"4491","unstructured":"Watson H. An account of a gouty body, dissected. Medical Communications 1784; 1: 86-94."},{"key":"4492","unstructured":"Parkinson J. Observations on the nature and cure of gout. London: H.D. Symonds, 1805: 5-9."},{"key":"4493","unstructured":"Ring J. A treatise on the gout. London: J. Callow, 1811."},{"key":"4494","unstructured":"Scudamore C. A further examination of the principles of the treatment of gout with observations on the use and abuse of colchicum. London: Longman, Rees, Orme, Brown, Green and Longman, 1833: 23."},{"key":"4495","unstructured":"Watson T. Lectures on the principles and practice of physic. Philadelphia: Lea and Blanchard, 1848: 814."},{"key":"4496","unstructured":"Garrod AB. The nature and the treatment of gout and rheumatic gout. London: Walton and Maberly, 1859: 186-8."},{"key":"4497","unstructured":"Loomis AL. A system of practical medicine (volume 4). Philadelphia: Lea Bors. and Company, 1898: 1017."},{"key":"4498","unstructured":"Peters C. England and the english. London: Hurst and Blackett, 1904."},{"key":"4499","doi-asserted-by":"crossref","unstructured":"Cleave, T. L. Saccharine disease: the master disease of our time. New Canaan: Keats Publishing, 1975: 175.","DOI":"10.1016\/B978-0-7236-0368-9.50016-1"},{"key":"4500","unstructured":"Buchanan WW, B\u00e1lint G, de Ceulaer K. Clinical examination of the musculoskeletal system. Philadelphia: Lippincot William and Wilkins, 1997: 55."}],"container-title":["Reumatismo"],"original-title":[],"link":[{"URL":"https:\/\/www.reumatismo.org\/index.php\/reuma\/article\/download\/1570\/979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.reumatismo.org\/index.php\/reuma\/article\/download\/1570\/979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T09:38:17Z","timestamp":1689586697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.reumatismo.org\/index.php\/reuma\/article\/view\/1570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,17]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,7,17]]}},"URL":"https:\/\/doi.org\/10.4081\/reumatismo.2023.1570","relation":{},"ISSN":["2240-2683","0048-7449"],"issn-type":[{"value":"2240-2683","type":"electronic"},{"value":"0048-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,17]]}}}