{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T11:10:03Z","timestamp":1749640203682,"version":"3.41.0"},"reference-count":15,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatismo"],"abstract":"<jats:p>We present a case of interstitial lung disease arising in the course of antisynthetase syndrome (ASSD) in a patient with axial spondyloarthritis (ax-SpA) undergoing tumor necrosis factor-\u03b1 (TNF-\u03b1) inhibitor therapy. Only two cases of ASSD in ax-SpA patients have been described in the literature, although with a different autoantibody profile. Only in one case, ASSD manifested with lung involvement, without the possible implication of TNF-\u03b1 inhibitors in the pathogenesis, as it occurred concurrently with spondyloarthritis. Our case is the first to emphasize the coexistence of ASSD with anti-glycyl tRNA synthetase antibodies and ax-SpA, reminding us of the possible, although rare, adverse effects on the lungs with TNF-\u03b1 inhibitors.<\/jats:p>","DOI":"10.4081\/reumatismo.2025.1756","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T11:01:53Z","timestamp":1739185313000},"source":"Crossref","is-referenced-by-count":0,"title":["Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-\u03b1 inhibitors"],"prefix":"10.4081","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4963-0663","authenticated-orcid":false,"given":"Maria","family":"Iacovantuono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Bonini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Di Biase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicio","family":"Magliacani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Domenico","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"doi-asserted-by":"publisher","key":"11386","DOI":"10.21037\/jtd-20-3328"},{"doi-asserted-by":"publisher","key":"11387","DOI":"10.1093\/rheumatology\/keac115"},{"doi-asserted-by":"publisher","key":"11388","DOI":"10.1136\/ard.2009.108233"},{"doi-asserted-by":"publisher","key":"11389","DOI":"10.55563\/clinexprheumatol\/8xj0b9"},{"doi-asserted-by":"publisher","key":"11390","DOI":"10.1007\/s11926-011-0176-8"},{"doi-asserted-by":"publisher","key":"11391","DOI":"10.4103\/lungindia.lungindia_4_18"},{"doi-asserted-by":"publisher","key":"11392","DOI":"10.1136\/ard.2007.078907"},{"doi-asserted-by":"publisher","key":"11393","DOI":"10.1136\/annrheumdis-2012-201800"},{"doi-asserted-by":"publisher","key":"11394","DOI":"10.3390\/jcm8112013"},{"doi-asserted-by":"publisher","key":"11395","DOI":"10.55563\/clinexprheumatol\/bjb2gf"},{"doi-asserted-by":"publisher","key":"11396","DOI":"10.1155\/2020\/8840642"},{"doi-asserted-by":"publisher","key":"11397","DOI":"10.1016\/j.jbspin.2007.01.028"},{"doi-asserted-by":"publisher","key":"11398","DOI":"10.1186\/s13075-019-1980-1"},{"doi-asserted-by":"publisher","key":"11399","DOI":"10.1155\/2014\/179180"},{"doi-asserted-by":"publisher","key":"11400","DOI":"10.3904\/kjim.2015.30.1.104"}],"container-title":["Reumatismo"],"original-title":[],"link":[{"URL":"https:\/\/www.reumatismo.org\/reuma\/article\/download\/1756\/1068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.reumatismo.org\/reuma\/article\/download\/1756\/1068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T10:33:28Z","timestamp":1749638008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.reumatismo.org\/reuma\/article\/view\/1756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.4081\/reumatismo.2025.1756","relation":{},"ISSN":["2240-2683","0048-7449"],"issn-type":[{"type":"electronic","value":"2240-2683"},{"type":"print","value":"0048-7449"}],"subject":[],"published":{"date-parts":[[2025,2,10]]}}}