{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:14:51Z","timestamp":1780114491617,"version":"3.54.0"},"reference-count":17,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatismo"],"abstract":"<jats:p>Hansen\u2019s disease, also known as leprosy, is often termed \u201cthe great imitator\u201d due to its diverse clinical presentations that can mimic various rheumatologic disorders. We present the case of a 34-year-old female who developed extensive purpuric rashes, initially raising suspicion of vasculitis. Laboratory investigations revealed triple-positive antiphospholipid antibodies. However, skin smears and histopathological examination confirmed a diagnosis of diffuse lepromatous leprosy complicated by Lucio phenomenon. This case highlights the importance of considering infectious etiologies, such as leprosy, in the differential diagnosis of vasculitis and rheumatologic diseases. Given the overlapping clinical features, a comprehensive patient history and careful interpretation of autoantibody tests are essential for achieving an accurate diagnosis.<\/jats:p>","DOI":"10.4081\/reumatismo.2025.1834","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T09:07:49Z","timestamp":1753088869000},"source":"Crossref","is-referenced-by-count":1,"title":["Lucio phenomenon and antiphospholipid antibodies in leprosy mimicking rheumatologic disorders: a case report"],"prefix":"10.4081","volume":"77","author":[{"given":"Rudy","family":"Hidayat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanda","family":"Damanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abirianty Priandani","family":"Araminta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melani","family":"Marissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela Putri","family":"Maharani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"13686","doi-asserted-by":"publisher","DOI":"10.13181\/mji.v28i1.1793"},{"key":"13687","unstructured":"World Health Organization. Global leprosy (\u200eHansen disease)\u200e update, 2023: elimination of leprosy disease is possible \u2013 time to act! Available from: https:\/\/www.who.int\/publications\/i\/item\/who-wer9937-501-521."},{"key":"13688","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/429698"},{"key":"13689","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2683-2"},{"key":"13690","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02567.x"},{"key":"13691","unstructured":"Sharma P, Kumar A, Tuknayat A, Thami GP, Kundu R. Lucio phenomenon: a rare presentation of Hansen\u2019s disease. J Clin Aesthet Dermatol 2019; 12: 35-8."},{"key":"13692","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13425"},{"key":"13693","doi-asserted-by":"publisher","DOI":"10.19100\/jdvi.v5i1.225"},{"key":"13694","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0903a13"},{"key":"13695","doi-asserted-by":"publisher","DOI":"10.1159\/000536370"},{"key":"13696","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/641989"},{"key":"13697","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-019-0094-4"},{"key":"13698","doi-asserted-by":"publisher","DOI":"10.1191\/096120300678828712"},{"key":"13699","doi-asserted-by":"publisher","DOI":"10.1590\/S0482-50042009000200009"},{"key":"13700","doi-asserted-by":"publisher","DOI":"10.47276\/lr.85.3.194"},{"key":"13701","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8705"},{"key":"13702","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21361"}],"container-title":["Reumatismo"],"original-title":[],"link":[{"URL":"https:\/\/www.reumatismo.org\/reuma\/article\/download\/1834\/1089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.reumatismo.org\/reuma\/article\/download\/1834\/1089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:01:10Z","timestamp":1764086470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.reumatismo.org\/reuma\/article\/view\/1834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,11,24]]}},"URL":"https:\/\/doi.org\/10.4081\/reumatismo.2025.1834","relation":{},"ISSN":["2240-2683","0048-7449"],"issn-type":[{"value":"2240-2683","type":"electronic"},{"value":"0048-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,21]]}}}