{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:23:58Z","timestamp":1777890238547,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rare Tumors"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Stromal tumors of the prostate are rare and only a few cases have been described in the literature, including exceptional cases of stromal tumors with unknown malignant potential (STUMP) and a fatal outcome in young patients. Morphologically distinguishing a STUMP from a stromal sarcoma of the prostate (PSS) is still a challenge. We describe the histopathological and immunohistochemical findings in a 34-year-old man with a malignant specialized cell stromal tumor of the prostate that was diagnosed initially as STUMP, and he developed lung metastases within a few months. The patient attended our hospital because of lower urinary tract symptoms, after having excreted tissue through the urethra a few months before. Ultrasonography and urethrocystoscopy examinations showed a mass arising from the verumontanum, and a transurethral resection (TUR) revealed a high-grade spindle cell sarcoma reminiscent of a phyllode tumor of the breast. The tumor cells were immunoreactive for vimentin, progesterone receptor and, focally, CD34. The preliminary histological findings were subsequently confirmed after radical prostatectomy. The patient developed bilateral lung metastases and died 25 months after the initial diagnosis. Although rare in young patients, the challenging differential diagnosis of STUMP and PSS means that a prostate STUMP diagnosis made on the basis of biopsy or TUR specimens also requires urethro-cystoscopic monitoring for the early detection of any progression to PSS. Radical prostatectomy should also be carefully considered.<\/jats:p>","DOI":"10.4081\/rt.2010.e57","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T08:21:00Z","timestamp":1287390060000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Prostatic Stromal Tumor with Fatal Outcome in a Young Man:                     Histopathological and Immunohistochemical Case Presentation"],"prefix":"10.1177","volume":"2","author":[{"given":"Piergiuseppe","family":"Colombo","sequence":"first","affiliation":[{"name":"Department of Pathology, IRCCS Istituto\r                Clinico Humanitas, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Luca","family":"Ceresoli","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and\r                Hematology, IRCCS Istituto Clinico Humanitas, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Boiocchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, IRCCS Istituto\r                Clinico Humanitas, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Taverna","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Istituto\r                Clinico Humanitas, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Grizzi","sequence":"additional","affiliation":[{"name":"Laboratories of Quantitative Medicine, IRCCS\r                Istituto Clinico Humanitas, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Bertuzzi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and\r                Hematology, IRCCS Istituto Clinico Humanitas, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and\r                Hematology, IRCCS Istituto Clinico Humanitas, Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Roncalli","sequence":"additional","affiliation":[{"name":"Department of Pathology, IRCCS Istituto\r                Clinico Humanitas, Milan;"},{"name":"University of Milan School of Medicine,\r                Milan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"bibr1-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000134580.71261.57"},{"key":"bibr2-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200606000-00004"},{"key":"bibr3-rt.2010.e57","unstructured":"EbleJN, SauterG, EpsteinJI, SesterhennIA. Pathology and Genetics of\n                        Tumours of the Urinary System and Male Genital Organs.\n                        Lyon, France: IARC\n                        Press, 2004,\n                        218\u201349. (World Health Organization\n                    Classification of Tumours.)"},{"key":"bibr4-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65974-5"},{"key":"bibr5-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199802000-00002"},{"key":"bibr6-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-1439(03)00120-0"},{"key":"bibr7-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65120-8"},{"key":"bibr8-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/67.4.324"},{"key":"bibr9-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)45733-8"},{"key":"bibr10-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36234-1"},{"key":"bibr11-rt.2010.e57","first-page":"534","volume":"110","author":"Manivel C","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"bibr12-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)43280-0"},{"key":"bibr13-rt.2010.e57","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4321\/S0004-06142005000900012","volume":"58","author":"Lara C","year":"2005","journal-title":"Arch Esp Urol"},{"key":"bibr14-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1080\/014850190947822"},{"key":"bibr15-rt.2010.e57","first-page":"29","volume":"54","author":"Segawa N","year":"2008","journal-title":"Hinyokika Kiyo"},{"key":"bibr16-rt.2010.e57","first-page":"296","volume":"116","author":"Young JF","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"bibr17-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/S1166-7087(07)78582-2"},{"key":"bibr18-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.10.011"},{"key":"bibr19-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00142"},{"key":"bibr20-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(90)80068-X"},{"key":"bibr21-rt.2010.e57","first-page":"52","volume":"93","author":"Kameoka H","year":"2002","journal-title":"Nippon Hinyokika Gakkai Zasshi"},{"key":"bibr22-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800676"},{"key":"bibr23-rt.2010.e57","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01417.x"}],"container-title":["Rare Tumors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4081\/rt.2010.e57","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/rt\/article\/viewFile\/1944\/2451","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4081\/rt.2010.e57","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4081\/rt.2010.e57","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:33:57Z","timestamp":1777613637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4081\/rt.2010.e57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.4081\/rt.2010.e57"],"URL":"https:\/\/doi.org\/10.4081\/rt.2010.e57","relation":{},"ISSN":["2036-3613","2036-3613"],"issn-type":[{"value":"2036-3613","type":"print"},{"value":"2036-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]},"article-number":"rt.2010.e57"}}