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Sense of coherence (SOC), a central construct of the salutogenic framework, has emerged as a key psychosocial resource for chronic illnesses. However, its association with diverse health-related outcomes in patients with breast cancer has not yet been systematically investigated. This systematic review examined the association between SOC and health-related outcomes in patients with breast cancer. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, and literature searches were conducted in PubMed, EMBASE, PsycINFO, and CINAHL from inception through October 2025. A total of 28 eligible studies were included. A higher SOC was consistently associated with greater psychological well-being and lower symptom burden, including pain, fatigue, and insomnia. SOC was also positively associated with quality of life (QoL), especially in the emotional, social, cognitive, and role-functioning domains. Some studies have suggested that a higher SOC is associated with more favorable QoL outcomes during the treatment phases. Evidence on the clinical prognosis is limited, with only one study examining survival outcomes reporting a positive association between SOC and survival. In conclusion, higher SOC was consistently associated with various health-related outcomes among patients with breast cancer, including psychological adjustment, symptom burden, and QoL. These findings suggest that higher SOC is associated with more favorable health-related functioning and overall well-being in this population.<\/jats:p>","DOI":"10.4082\/kjfm.26.0005","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:08:34Z","timestamp":1784531314000},"page":"289-300","update-policy":"https:\/\/doi.org\/10.4082\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sense of coherence and health-related outcomes among patients with breast cancer: a systematic review"],"prefix":"10.4082","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3353-3317","authenticated-orcid":true,"given":"Hyu Jung","family":"Choe","sequence":"first","affiliation":[{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4338-0063","authenticated-orcid":true,"given":"Da Min","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2736-4611","authenticated-orcid":true,"given":"Seo Yeong","family":"An","sequence":"additional","affiliation":[{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7575-6243","authenticated-orcid":true,"given":"Yun Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-4271","authenticated-orcid":true,"given":"Justin Y.","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Korea"},{"name":"Center for Exercise Medicine and Salutogenesis, Institute of Convergence Science, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1329-4637","authenticated-orcid":true,"given":"Dong Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Sport Industry Studies, Yonsei University, Seoul, Korea"},{"name":"Department of Nutrition, Harvard T. 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