{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:39:47Z","timestamp":1792269587556,"version":"4.4.0"},"reference-count":10,"publisher":"The Korean Academy of Family Medicine - M2PI","issue":"5","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["kjfm.or.kr"],"crossmark-restriction":true},"short-container-title":["Korean J Fam Med"],"published-print":{"date-parts":[[2026,9,20]]},"abstract":"<jats:p>Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used for obesity management; however, concerns have recently emerged regarding potential ocular adverse events, including nonarteritic anterior ischemic optic neuropathy (NAION). Herein, we report a case of NAION that developed after marked, rapid weight loss during semaglutide therapy in a young man with multiple vascular risk factors. A 42-year-old man presented with acute visual disturbance in the right eye after losing approximately 40 kg over 2 months while receiving semaglutide (Wegovy) for obesity treatment. The patient\u2019s medical history included diabetes mellitus, hypertension, dyslipidemia, and a history of smoking. Ophthalmic examination revealed right optic disc edema and a corresponding inferior visual field defect. Magnetic resonance imaging and laboratory investigations revealed no other definite causes of optic neuropathy. He was diagnosed with NAION, which was temporally associated with semaglutide therapy and rapid weight reduction. Semaglutide was discontinued, and high-dose intravenous methylprednisolone was administered. At 6 months, the optic disc edema had resolved, leaving mild disc pallor, though the visual field defect persisted. Although causality cannot be established from a single case, this report highlights the need for clinical vigilance regarding optic neuropathy in patients receiving semaglutide, particularly in the setting of rapid weight loss.<\/jats:p>","DOI":"10.4082\/kjfm.26.0135","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:46:37Z","timestamp":1789951597000},"page":"460-464","update-policy":"https:\/\/doi.org\/10.4082\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nonarteritic anterior ischemic optic neuropathy after rapid weight loss during semaglutide therapy: a case report"],"prefix":"10.4082","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4739-0048","authenticated-orcid":true,"given":"Chan-Ho","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8869-0349","authenticated-orcid":true,"given":"Won Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2550","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(22)00008-0","type":"journal-article"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1607141","type":"journal-article"},{"key":"ref3","first-page":"304","type":"journal-article","volume-title":"Semaglutide and nonarteritic anterior ischemic optic neuropathy","author":"Cai","year":"2025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2024.2296","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2025.0349","type":"journal-article"},{"key":"ref6","first-page":"3094","type":"journal-article","volume-title":"Use of semaglutide and risk of non-arteritic anterior ischemic optic neuropathy: a Danish-Norwegian cohort study","author":"Simonsen","year":"2025"},{"key":"ref7","first-page":"101","type":"book","volume-title":"","author":"Pineles","year":"2019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2025.02.025","type":"journal-article"},{"key":"ref9","first-page":"381","type":"journal-article","volume-title":"Association between semaglutide and nonarteritic anterior ischemic optic neuropathy: a multinational population-based study","author":"Chou","year":"2025"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2025.6262","type":"journal-article"}],"container-title":["Korean Journal of Family Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/kjfm.or.kr\/upload\/pdf\/kjfm-26-0135.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/kjfm.or.kr\/journal\/view.php?doi=10.4082\/kjfm.26.0135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/kjfm.or.kr\/upload\/pdf\/kjfm-26-0135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:51:29Z","timestamp":1790128289000},"score":1,"resource":{"primary":{"URL":"http:\/\/kjfm.or.kr\/journal\/view.php?doi=10.4082\/kjfm.26.0135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.4082\/kjfm.26.0135","relation":{},"ISSN":["2092-6715"],"issn-type":[{"value":"2092-6715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}