{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:32:19Z","timestamp":1773682339010,"version":"3.50.1"},"reference-count":0,"publisher":"Institute of Hematology, Catholic University","issue":"1","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering from Graves\u2019 disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter, and thyro-gastric syndrome. Antithyroid drug therapy was stopped resulting in a worsening of thyrotoxicosis. Agranulocytosis was treated with 8 doses of G-CSF with full recovery. To rapidly restore euthyroidism and to perform a thyroidectomy, the patient received 6 plasmapheresis procedures, to clear thyroid hormones and anti-TSH receptor antibodies from the blood, resulting in a pre-surgical euthyroid state without antithyroid drugs. One year after thyroidectomy, the patient is well on thyroid hormone replacement therapy.\u00a0Key Words:\u00a0Plasmapheresis; Hyperthyroidism, Agranulocytosis; Propylthiouracil.<\/jats:p>","DOI":"10.4084\/mjhid.2017.058","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T06:51:04Z","timestamp":1508395864000},"page":"e2017058","source":"Crossref","is-referenced-by-count":5,"title":["Graves\u2019 disease thyrotoxicosis and propylthiouracil related agranulocytosis successfully treated with therapeutic plasma exchange and g-csf followed by total thyroidectomy."],"prefix":"10.4084","volume":"9","author":[{"given":"Anna","family":"Candoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2554","published-online":{"date-parts":[[2017,10,16]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/viewFile\/3065\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/viewFile\/3065\/html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/viewFile\/3065\/html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T06:51:04Z","timestamp":1508395864000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/view\/2017.058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,16]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,26]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2017.058","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,16]]}}}