{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:41:03Z","timestamp":1772628063106,"version":"3.50.1"},"reference-count":0,"publisher":"Institute of Hematology, Catholic University","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Background: The incidence and biology of non-Hodgkin lymphoma (NHL) vary according to age. Some data suggest that the impact of age in pediatric and adolescent NHL patients depends on the histological subtype. Objectives: We aimed to analyze the impact of age at diagnosis on clinical characteristics and treatment-related toxicity in children and adolescents with NHL.Methods: Retrospective review of medical records of children and adolescents diagnosed with NHL at the Hospital for Sick children, Toronto, between January 1995 and December 2008.Results: 164 children were diagnosed with NHL during the study period, with a median age at diagnosis of 10 years. With a median follow-up of 6.2 years, 5-year OS in patients aged &lt;15 and 15-18 years was 89\u00b1 2% vs 82% \u00b1 6%, respectively (P = 0.30), and 5-year EFS was 84% \u00b1 3% vs. 77% \u00b1 7%\u00a0 (P= 0.37). In Burkitts lymphoma (BL) and lymphoblastic lymphoma (LL) there was a trend towards better outcomes in children compared to adolescents, with EFS of\u00a0 91% \u00b1 4% vs. 75% \u00b1 15%, respectively in BL (P= 0.17),\u00a0 and 82% \u00b1 7% vs. 51.4% \u00b1 2% respectively in LL (P= 0.16). Late effects occurred in 21 patients (12.8%).Conclusions: Children with NHL aged &lt; 15 years tend to have better survival rates and less long-term toxicity than adolescents aged 15-18 years.<\/jats:p>","DOI":"10.4084\/mjhid.2018.020","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T13:01:39Z","timestamp":1519650099000},"page":"e2018020","source":"Crossref","is-referenced-by-count":6,"title":["OUTCOME AND TOXICITY PATTERNS IN CHILDREN AND ADOLESCENTS WITH NON-HODGKIN LYMPHOMA: A SINGLE INSTITUTION EXPERIENCE"],"prefix":"10.4084","volume":"10","author":[{"given":"Paola","family":"Angelini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Zolaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Weitzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oussama","family":"Abla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2554","published-online":{"date-parts":[[2018,3,1]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/viewFile\/3239\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/viewFile\/3239\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T13:01:39Z","timestamp":1519650099000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.mjhid.org\/index.php\/mjhid\/article\/view\/2018.020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12,27]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2018.020","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]}}}