{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:58:44Z","timestamp":1761897524778},"reference-count":0,"publisher":"Institute of Hematology, Catholic University","issue":"1","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Considerable data indicate\u00a0posttransplant lenalidomide prolongs progression-free survival and probably survival after an autotransplant for plasma cell myeloma (PCM).\u00a0 However, optimal therapy duration is unknown, controversial and differs\u00a0in the EU and US.\u00a0 We compared outcomes and\u00a0cost-effectiveness of 3 posttransplant lenalidomide strategies\u00a0in EU and US settings:\u00a0(1) none; (2) until failure; and (3) 2-year fixed duration.\u00a0 We used a Markov decision model which included 6 health states and informed by published data.\u00a0 The model estimated the strategy of lenalidomide given to failure achieved 1.06 quality-adjusted life years (QALYs) at costs\u00a0per\u00a0QALY gained of\u00a0\u20ac29,232 in the EU\u00a0 \u00a0and\u00a0$133,401 in the US settings.\u00a0 Two-year fixed-duration lenalidomide\u00a0averted \u20ac7,286\u00a0per\u00a0QALY gained in the EU setting and saved 0.84 QALYs at $60,835\u00a0per\u00a0QALY gained in the US setting.\u00a0\u00a0These extremely divergent costs\u00a0per\u00a0QALY in the EU and US settings resulted from large differences in costs of posttransplant lenalidomide and of 2nd-line therapies driven by whether posttransplant failure was on- or off-lenalidomide.\u00a0 In Monte Carlo simulation analyses which allowed us to account for variability of inputs, 2-year fixed-duration lenalidomide remained the preferred strategy for improving health-care sustainability in\u00a0the EU and US settings.<\/jats:p>","DOI":"10.4084\/mjhid.2021.034","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T17:37:46Z","timestamp":1619717866000},"source":"Crossref","is-referenced-by-count":4,"title":["COST-EFFECTIVENESS OF POST-AUTOTRANSPLANT LENALIDOMIDE  IN PERSONS WITH MULTIPLE MYELOMA."],"prefix":"10.4084","volume":"13","author":[{"given":"Monia","family":"Marchetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Peter","family":"Gale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2554","published-online":{"date-parts":[[2021,4,29]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/download\/4555\/4006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/download\/4555\/4009","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/download\/4555\/4006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T17:37:46Z","timestamp":1619717866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/view\/4555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2021.034","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]}}}