{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:40:33Z","timestamp":1790768433377,"version":"4.1.0"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Aims: The primary aim of this study was to evaluate retrospectively the glucose homeostasis and surrogate indexes of insulin sensitivity and resistance, during a 3-hour oral glucose tolerance test (OGTT), in \u03b2- thalassemia major patients (\u03b2-TM) with serum ferritin (SF) below 1,000 ng\/mL.\r\nPatients and methods: The retrospective cohort study evaluated the medical records of 24 \u03b2-\u03a4\u039c patients from 2010 to 2022. \u0391t the year of study the mean age of patients was 31.0 \u00b1 4.1 (20-37.11) years; 13 (54.1%) were females. The most commonly used iron chelator was deferoxamine (DFO: 75%), followed by deferiprone (DFP:12.5%) and deferasirox (DFX: 12.5%). Insulin sensitivity and resistance indexes were derived from OGTT. A liver iron concentration (LIC) &lt; 3 mg\/g d.w. and a global heart T2* value &lt; 20 ms were considered as conservative cut-off values for insignificant iron overload (IOL).\r\nResults: The mean SF levels in the whole study cohort population at the age of evaluation was 549.6 \u00b1 232.3 ng\/mL. Based on the SF levels, two groups were identified: Group A (N = 14) &lt; 500 ng\/mL and Group B (N=10) 500-1,000 ng\/mL. \u00a0Normal glucose tolerance (NGT) during OGTT was observed in 4 patients of Group A (28.5 %) and in 5 patients of Group B (50%) (P: 0.29). The remaining 15\/24 patients (62.5%) had glucose dysregulation (GD). The mean age at starting iron chelation therapy (ICT) and the mean SF peak in Group A versus Group B were significantly higher in group \u0391. \u00a0The GD was \u00a0associated with significantly attenuated IGI (first phase of insulin response) and impaired oral disposition index (oDI). Hypogonadotropic hypogonadism (HH) was the most common associated endocrine complication in both groups of patients.\r\nConclusions: This study showed that efficient iron chelation monotherapy in patients with \u03b2-TM and SF &lt; 1,000 ng\/ml did not entirely prevent glucose metabolism disorders, insulin secretion and sensitivity, and development of acquired hypogonadism.<\/jats:p>","DOI":"10.4084\/mjhid.2023.006","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T13:02:09Z","timestamp":1672664529000},"page":"e2023006","source":"Crossref","is-referenced-by-count":4,"title":["GLUCOSE HOMEOSTASIS AND \u0391SSESSMENT OF \u0392-CELL FUNCTION BY 3-HOUR ORAL GLUCOSE TOLERANCE (OGTT) IN PATIENTS WITH \u0392-THALASSEMIA MAJOR WITH SERUM FERRITIN BELOW 1,000 NG\/DL: RESULTS FROM A SINGLE ICET-A CENTRE"],"prefix":"10.4084","volume":"15","author":[{"given":"Vincenzo","family":"De Sanctis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahina","family":"Daar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ploutarchos","family":"Tzoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Kattamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2023,1,1]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/download\/5154\/4282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/download\/5154\/4284","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/download\/5154\/4282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T13:02:10Z","timestamp":1672664530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/index.php\/mjhid\/article\/view\/5154"}},"subtitle":["OGTT in thalassemia and iron overload"],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2023.006","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,1]]}}}