{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:42:29Z","timestamp":1787794949499,"version":"build-2784847793"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>The introduction of arsenic trioxid (ATO) associated to all-trans retinoic acid (ATRA) is the therapeutic standard for standard-risk acute promyelocytic leukemia (APL). ATO has been shown to induce dysplastic changes on bone marrow progenitor cells. Despite that, observational studies evaluating bone marrow morphology during follow-up of APL patients treated with the ATRA-ATO combination are lacking. Hence, we conducted a retrospective study to evaluate morphological characteristics of bone marrow smears at different time-points during the follow up of 8 patients successfully treated with ATRA-ATO (end of consolidaton and 12 monts after end of therapy), as compared to those of 3 patients treated with the AIDA protocol. At 12 months after end of treatment, we highlighted higher grade of megakaryocytic dysplasia and increased promonocyte counts in patients treated with ATRA\/ATO versus AIDA (p=0.026 and p=0.030 respectively), suggesting a long-term dysplastic effect of arsenic trioxide. Despite the morphological alterations described, none of the patients treated with ATRA-ATO developed cytopenia or a secondary myeloid neoplasm during follow-up, configuring an \u201cidiopathic dysplasia of unknown significance\u201d (IDUS).<\/jats:p>","DOI":"10.4084\/mjhid.2025.038","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:45:12Z","timestamp":1746092712000},"page":"e2025038","source":"Crossref","is-referenced-by-count":2,"title":["Long-term persistence of dysplastic features in patients with Acute Promyelocytic Leukemia  treated with all-trans retinoic acid and arsenic trioxide."],"prefix":"10.4084","volume":"17","author":[{"given":"Enrico","family":"Santinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Pascale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guarnera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Savi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Mallegni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Gurnari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Maurillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Voso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Fenu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2025,4,30]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/5964\/4675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/5964\/4679","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/5964\/4675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T10:20:50Z","timestamp":1746440450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/5964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2025.038","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}