{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:27:39Z","timestamp":1782512859438,"version":"3.54.5"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Objective:\u00a0To investigate the differences in clinical characteristics between Gram-positive and Gram-negative neonatal sepsis (NS). Methods:\u00a0A retrospective analysis was conducted on a total of 150 patients admitted between March 2019 and March 2024. . The 91 NS patients were divided into Gram-negative bacteria group (n=31) and Gram-positive bacteria group (n=60). Sixty (n=60) non-septic neonates served as controls and general information was collected on all participants. C-reactive protein\u00a0(CRP), procalcitonin\u00a0(PCT) and platelets (PLT) were independent influencing factors for differentiating infections caused by the two pathogens. The onset symptoms, strain distribution, and pretreatment various biochemical parameters were compared among the three groups. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy. Results:\u00a0The proportions of patients with amniotic fluid contamination and fever (body temperature \u2265 38. 0 \u2103) were higher in the Gram-negative group than in the Gram-positive group (P=0.023, 0.049).\u00a0The concentrations for CRP, PCT\u00a0and PLT were P=0.019, 0.023, 0.030 respectively. ROC curve analysis revealed that the specificity of the combination of CRP, PCT and PLT in diagnosing Gram-negative bacterial infection was 100.00%, and the area under the curve (AUC) was 0.904, which were higher than those of single indicators (P=0.05). Conclusion:\u00a0There are differences in the expression of CRP, PCT and PLT between Gram-positive and Gram-negative NS. The simultaneous detection of the three has a high diagnostic value in differentiating infections caused by the two pathogens.<\/jats:p>","DOI":"10.4084\/mjhid.2025.048","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T11:20:09Z","timestamp":1751196009000},"page":"e2025048","source":"Crossref","is-referenced-by-count":3,"title":["ANALYSIS OF CLINICAL CHARACTERISTICS AND DIAGNOSTIC EFFICACY OF BLOOD INDICATORS IN NEONATAL SEPSIS WITH DIFFERENT PATHOGENIC BACTERIA"],"prefix":"10.4084","volume":"17","author":[{"given":"You-Hong","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Bao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2025,6,29]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/5953\/4721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/5953\/4722","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/5953\/4721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T11:20:09Z","timestamp":1751196009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/5953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,29]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2025.048","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,29]]}}}