{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:31:46Z","timestamp":1783722706535,"version":"3.55.0"},"reference-count":0,"publisher":"Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediterr J Hematol Infect Dis"],"abstract":"<jats:p>Background: Thalassemia is a common hereditary hemoglobin disorder in Vietnam. Elucidating the epidemiological and genetic patterns in children is essential for developing screening and prevention strategies.\r\nMethods: A retrospective analysis of 1,240 children under 10 years of age with Thalassemia treated at the National Institute of Hematology and Blood Transfusion in Vietnam, between 2014 and 2023.\r\nResults: The median age at treatment initiation was 1 year (range 0-9 years), with 94.5% of patients being the age 0-5 years. Children born after 2020 were diagnosed and treated earlier than those born before 2020 (0 year (range 0-2 years) vs 1 year (range 0-9 years); p &lt; 0.0001), concurrent with the implementation of the national prenatal screening program. \u03b2-thalassemia and \u03b2-thalassemia\/HbE accounted for nearly 90% of cases, with subtype distribution varying by ethnicity and region. \u03b2-thalassemia\/HbE predominated in the Northwest and North Central regions, particularly among the Thai and Muong populations. In contrast, \u03b2-thalassemia was more prevalent in the Northeast, notably among the Tay and Nung populations. Eight \u03b1-globin and thirteen \u03b2-globin mutated types were detected. The common \u03b2-globin variants (Cd17, Cd41\/42, Cd71\/72, -28, and IVSI-1) and HbE (Cd26), mirror patterns reported in neighboring Laos and Guangxi Province, China. For \u03b1-globin genotypes, --SEA (49.83%), HbCS (31.53%), and -\u03b13.7 (8.47%) were most frequent.\r\nConclusion: Geography, ethnicity, and genetic background strongly shape Thalassemia epidemiology in Northern Vietnam. Targeted genetic counseling, early carrier screening, and region-focused community programs are urgently needed to reduce disease burden in high-risk populations.<\/jats:p>","DOI":"10.4084\/mjhid.2026.002","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:55:49Z","timestamp":1767279349000},"page":"e2026002","source":"Crossref","is-referenced-by-count":1,"title":["SUBTYPE DISTRIBUTION AND MUTATION SPECTRUM THALASSEMIA IN CHILDREN UNDER 10 YEARS IN NORTHERN VIETNAM"],"prefix":"10.4084","volume":"18","author":[{"given":"Ngoc Dung","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Thanh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Chi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Nguyet Anh","family":"Phi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thu Ha","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thu Huyen","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Linh","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc Binh","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2554","published-online":{"date-parts":[[2026,1,1]]},"container-title":["Mediterranean Journal of Hematology and Infectious Diseases"],"original-title":[],"link":[{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6102\/4793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6102\/4796","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/download\/6102\/4793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T19:22:48Z","timestamp":1767295368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mjhid.org\/mjhid\/article\/view\/6102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.4084\/mjhid.2026.002","relation":{},"ISSN":["2035-3006"],"issn-type":[{"value":"2035-3006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}